Tuesday, October 28, 2025 10/28/2025

Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

Award Number: K24AI177947
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/12/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

Group Awards By:

View Award Description

Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease - PROJECT SUMMARY Chronic rhinosinusitis (CRS) is a common inflammatory disease that affects a large portion of the U.S. population, resulting in poor quality of life for those affected and utilizing billions of dollars of health care resources. Efforts in my lab have focused on understanding patterns of inflammatory heterogeneity in large CRS populations with a goal of improving disease endotyping and developing personalized care pathways. I am devoted to mentoring the next generation of clinician-scientists in the field of rhinology and chronic rhinosinusitis research. The number of physicians and other surgeons pursuing clinical or translational research is declining, and this is particularly true in the fields of rhinology and otolaryngology. Maintaining a strong pipeline of trainees on research-related career paths is crucial for the development of the subspecialty and scientific advancement of the field. This will be a prospective translational cohort study to identify the clinical implications and longitudinal stability of chronic rhinosinusitis endotypes. We will enroll CRS patients through our well-established biospecimen repository and determine the stability of inflammatory mediator levels and associated endotype assignment over multiple seasons and determine whether these changes are associated with sinonasal microbial community structure. We will also confirm the longitudinal effects of two commonly used immune-modifying interventions (endoscopic sinus surgery and anti-IL4/13R biologic therapy) on inflammatory mediator levels and endotypic assignment. Collectively, these translational studies will substantially advance basic knowledge of a common airway disease that impacts millions of patients, while providing a range of investigative opportunities for mentees interested in CRS and mechanisms of upper airway inflammation. My research program is centered around a patient-oriented approach that incorporates patient-derived specimens, patient-reported outcome measures, and personalized approaches to care. I anticipate that mentee participation in this research program will lead to new and exciting avenues for patient-oriented research to further characterize CRS endotypes and evaluate the effects of targeted therapies; thus, this project will provide a conducive setting for developing the next generation of clinician-scientists in the field. I have a history of continual extramural funding, more than a decade of experience as a mentor to trainees at all levels, and institutional support to enhance my own skills that will augment the support proposed through the K24 mechanism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $112,728 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	3	7/16/2025	NON-COMPETING CONTINUATION	$112,728
2025	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	1	2/11/2025	NEW	$0
														Subtotal = $112,728

Issue Date FY: 2024 ( Subtotal = $115,969 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	2	8/21/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$115,969
2024	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	1	8/21/2024	NEW	$0
														Subtotal = $115,969

Issue Date FY: 2023 ( Subtotal = $115,968 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Allergy and Infectious Diseases Research	000	1	7/12/2023	NEW	$115,968
														Subtotal = $115,968

Grand Total All Awards = $344,665

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mentoring in Chronic Rhinosinusitis Pathophysiology and Mechanisms of Disease

Award Number: K24AI177947

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/12/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer