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Midcareer Investigator Award in Patient-Oriented Research to Optimize Hypertension Management in Aging

Award Number: K24AG093099
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Midcareer Investigator Award in Patient-Oriented Research to Optimize Hypertension Management in Aging - PROJECT SUMMARY Hypertension prevalence increases with aging and is the foremost modifiable risk factor for Alzheimer’s disease (AD) and AD-related dementias (ADRD). Certain antihypertensive classes may impact the pathogenesis of AD/ADRD. Targeting individuals who are most likely to attain cognitive benefit from these antihypertensive classes could prevent AD/ADRD in millions of US adults. However, several factors may deter optimally implementing targeted antihypertensive treatment strategies in older adults that merit further investigation. This K24 proposal will allow the principal investigator, Dr. Jordana Cohen, protected time and support to expand her mentoring skills and her patient-oriented research program. Her short-term career goals are to (1) strengthen her mentoring skills in a broad group of trainees and early-stage investigators; (2) gain new research skills in the prospective assessment of cognitive outcomes and the analysis of heterogeneity of treatment effects within the framework of target trial emulation; and (3) expand upon her existing infrastructure to develop a Hypertension in Aging Research Training Program. Her mentoring program focuses on precision mentoring that is individualized to mentees’ needs, complemented by broader training on leadership, research, and writing skills to prepare the next generation of team scientists. For the research aims, Dr. Cohen will leverage her funded research projects and existing resources at the University of Pennsylvania to provide distinctive training opportunities that are new areas of focus for her, aligned with each mentee’s career stage and desired path, and will inform and support new K and R01 submissions to design and test interventions to optimize antihypertensive medication strategies, aiming to ultimately prevent AD/ADRD. Mentee dyads composed of mentees with complementary experience and interests will synergize to co-lead each of the aims under Dr. Cohen’s mentorship and supported by her mentoring team. The research aims are to (1) determine comparative effects of angiotensin II receptor blockers (ARBs) vs. angiotensin-converting enzyme inhibitors (ACEIs) on cognitive outcomes in the Chronic Renal Insufficiency Cohort (CRIC) Study and the Veterans Health Administration (VHA), focusing on heterogeneity of treatment effects across age, frailty, and APOEε4; (2) determine if vascular aging and blood pressure control modify the effects of ARBs vs. ACEIs on cognitive outcomes in CRIC and the VHA; and (3) determine the accuracy, useability, and uptake of a commonly used home blood pressure monitor in older patients (aged ≥80 years), which will explore aging-related factors that may affect sustained home blood pressure monitoring. These studies will yield a better understanding of how to optimize antihypertensive treatment strategies to maximize the public health impact on brain health. This proposed K24 career development, mentoring, and research plan will also develop preliminary data to inform Dr. Cohen’s mentees' K23 and R01 grant submissions to better target antihypertensive medications and blood pressure management strategies in the >100 million aging adults with HTN.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $212,064 )
2026	2026	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Aging Research	000	1	7/1/2026	NEW	$212,064
														Subtotal = $212,064

Grand Total All Awards = $212,064

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Midcareer Investigator Award in Patient-Oriented Research to Optimize Hypertension Management in Aging

Award Number: K24AG093099

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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