Thursday, September 18, 2025 9/18/2025

Dynamic Risk Prediction of Life-Threatening Mass Effect After Ischemic Stroke

Award Number: K23NS116033
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

Group Awards By:

View Award Description

Dynamic Risk Prediction of Life-Threatening Mass Effect After Ischemic Stroke - PROJECT SUMMARY/ABSTRACT Dr. Ong is a neurologist and young investigator pursuing patient-oriented clinical research. For this K-23 submission, she will develop a novel framework for dynamic risk prediction of life-threatening mass effect after ischemic stroke using both baseline and longitudinal variables through the first 120 hours after admission. A K23 award will provide her with the means to acquire critical career development skills that will enable her to execute and build upon her project including: 1) dynamic risk prediction and trajectory analysis; 2) multi-modal methods of neuroprognostication; 3) clinical trial design; and 4) professional development. These objectives will help Dr. Ong to achieve her long-term career goal of becoming an independent clinical investigator of data- driven tools that support clinical decision making and optimize outcomes after acute brain injury. Dr. Ong has recruited a multi-disciplinary mentorship team to assist her in executing her project and achieving scientific independence. She will be co-mentored by Dr. David Greer, an R01 funded clinician scientist with expertise in neurocritical care, neuroprognostication, and clinical study design, and Dr. Emelia Benjamin, an R01 funded leading cerebrovascular epidemiologist and risk prediction specialist with extensive mentorship experience. Dr. Josée Dupuis, Chair of Biostatistics at Boston University School of Public Health, will serve as a methodologic mentor overseeing Dr. Ong’s progress in dynamic modeling strategies. Dr. Ong’s overarching hypothesis is that dynamic risk models that update their predictions with newly available longitudinal data will improve prediction of Life-Threatening Mass Effect and better support clinical decision making in real-time. Aim 1 will use a retrospective medical record dataset of 3000 large stroke patients to identify variables trajectories predictive of radiographic LTME, and use this information to develop updating multivariable dynamic risk models of LTME comprised of baseline and longitudinal variables for the first 120 hours of admission. In Aim 2, she will study the relationship of hourly quantitative pupillometry and LTME through the prospective recruitment of 60 patients with large stroke, and develop an exploratory dynamic multivariable model of LTME using Dr. Ong’s proposed research is significant because improving LTME prediction can facilitate more timely life- and function-sparing interventions. Her research is innovative because she will develop and apply a novel dynamic risk modeling framework to predict secondary injury following ischemic stroke, and study the new promising longitudinal variable, quantitative pupillometry. predictive variables identified in Aim 1 as well as hourly pupillometry data. Her aims, training plan, and interdisciplinary mentorship team will prepare Dr. Ong to become an independent investigator of data-driven tools that support clinical decision making and optimize outcomes after acute brain injury. The anticipated results will be strong preliminary data for a R01 proposal testing the effect of dynamic LTME assessments on time to intervention and outcome in clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $218,759 )
2025	2025	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/24/2025	NON-COMPETING CONTINUATION	$216,099
2025	2025	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	5/5/2025	NON-COMPETING CONTINUATION	$2,660
														Subtotal = $218,759

Issue Date FY: 2024 ( Subtotal = $217,494 )
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	5/14/2024	NON-COMPETING CONTINUATION	$33,250
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/29/2024	NON-COMPETING CONTINUATION	$184,244
														Subtotal = $217,494

Issue Date FY: 2023 ( Subtotal = $218,848 )
2023	2023	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/23/2023	NON-COMPETING CONTINUATION	$218,848
														Subtotal = $218,848

Issue Date FY: 2022 ( Subtotal = $186,515 )
2022	2022	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/1/2022	NON-COMPETING CONTINUATION	$186,515
														Subtotal = $186,515

Issue Date FY: 2021 ( Subtotal = $188,190 )
2021	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/29/2021	NEW	$188,190
														Subtotal = $188,190

Grand Total All Awards = $1,029,806

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Dynamic Risk Prediction of Life-Threatening Mass Effect After Ischemic Stroke

Award Number: K23NS116033

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer