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DIALECTICAL BEHAVIOR THERAPY FOR EARLY NON-RESPONDERS TO CBT WITH BINGE EATING DI

Award Number: K23MH081030
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/24/2008
PERIOD OF PERFORMANCE END DATE: 03/31/2014

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DIALECTICAL BEHAVIOR THERAPY FOR EARLY NON-RESPONDERS TO CBT WITH BINGE EATING DI - DESCRIPTION (provided by applicant): Binge Eating Disorder (BED) is a significant public health problem, with serious medical and psychosocial consequences. The most established treatment for BED is Cognitive Behavioral Therapy (CBT). Early response appears to predict good outcome in CBT for BED, while poor outcome may be predicted by more extreme emotion dysregulation. Standard Dialectical Behavior Therapy (DBT) is a group and individual therapy developed for individuals for whom other treatments have failed and who have extreme emotion dysregulation. A less intense (group only) version of DBT is efficacious for BED. A case series utilizing DBT with individuals with extreme emotion dysregulation (i.e., borderline personality disorder) and BED, suggests that DBT may be useful for 'difficult-to-treat' eating disorders. The Primary Aim of this K-23 is to examine the efficacy of standard DBT compared to CBT+ (individual plus group CBT) in women with BED who have early non-response to individual CBT. The primary objective of this K-23 is to enhance my skill in the conduct of complex clinical trials and to examine whether standard DBT is promising for early non-responders to CBT. Women meeting criteria for BED who are early non-responders to CBT, i.e., do not decrease their binge eating by 65% within the first 4 weeks of individual CBT, will be randomized to six-months of standard DBT or CBT+. The primary hypothesis is that standard DBT is more efficacious than CBT+ for early non-responders to CBT in achieving binge-eating abstinence and reduction. Compared to CBT+, DBT will show greater reduction 1) secondary eating disorder behaviors, 2) therapy-interfering behaviors; and greater improvement in: 3) general psychopathology (e.g., drug and alcohol abuse), and 4) psychosocial functioning. These hypotheses will be tested at post-treatment and at 3-month intervals for one year. The study will also assess the feasibility and acceptability of using psychophysiology (e.g., respiratory sinus arrhythmia), laboratory (mood induction and an interpersonal problem-solving task), and experience sampling (using a palm pilot to monitor every-day mood and behavior) tasks within the context of a randomized controlled trial. These measures will be used in an exploratory way to examine the moderators and mediators of treatment, derived from the DBT model of emotion dysregulation. Findings from the study will be used to determine a future R01 grant application


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = -$12,842 )
2013	2012	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Mental Health Research Career/Scientist Development Awards	000	6	1/10/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$12,842
														Subtotal = -$12,842

Issue Date FY: 2012 ( Subtotal = $141,550 )
2012	2012	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Mental Health Research Career/Scientist Development Awards	003	6	8/16/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$503
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	000	5	3/15/2012	NON-COMPETING CONTINUATION	$142,347
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	001	5	8/7/2012	NON-COMPETING CONTINUATION	-$115,688
2012	2012	TEMPLE UNIVERSITY	BROAD & MONTGOMERY AVENUE	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Mental Health Research Career/Scientist Development Awards	002	6	8/7/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$115,394
														Subtotal = $141,550

Issue Date FY: 2011 ( Subtotal = $143,343 )
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	000	4	3/15/2011	NON-COMPETING CONTINUATION	$143,343
														Subtotal = $143,343

Issue Date FY: 2010 ( Subtotal = $140,740 )
2010	2010	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	000	3	3/12/2010	NON-COMPETING CONTINUATION	$140,740
														Subtotal = $140,740

Issue Date FY: 2009 ( Subtotal = $138,215 )
2009	2009	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	000	2	3/16/2009	NON-COMPETING CONTINUATION	$138,215
														Subtotal = $138,215

Issue Date FY: 2008 ( Subtotal = $135,222 )
2008	2008	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Mental Health Research Career/Scientist Development Awards	000	1	4/24/2008	NEW	$135,222
														Subtotal = $135,222

Grand Total All Awards = $686,228

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DIALECTICAL BEHAVIOR THERAPY FOR EARLY NON-RESPONDERS TO CBT WITH BINGE EATING DI

Award Number: K23MH081030

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/24/2008

PERIOD OF PERFORMANCE END DATE: 03/31/2014

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