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Advancing Sustainable Obesity Care: Integrating Food is Medicine with GLP-1 Receptor Agonists

Award Number: K23HL186120
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Advancing Sustainable Obesity Care: Integrating Food is Medicine with GLP-1 Receptor Agonists - PROJECT SUMMARY Obesity is one of the most pressing public health challenges in the United States, with widespread consequences for chronic disease, including cardiovascular disease, and escalating healthcare costs. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a promising pharmacologic treatment, offering significant weight loss and cardiometabolic benefits. However, their long-term use is limited by concerns about safety, cost-effectiveness, and feasibility for broad, population-wide adoption, implementation, and maintenance. Moreover, GLP-1 RAs may not directly improve overall dietary behavior, which is essential for achieving long-term obesity management. Dr. Yoo’s K23 career development proposal aims to evaluate the integration of a Food is Medicine (FIM) implementation bundle for patients initiating GLP-1 RA for weight management through a type 1 hybrid randomized trial embedded in WashU Medicine/BJC HealthCare, in partnership with Season Health, a national FIM provider. The study include: (1) formative mixed-methods research to guide adaptation of the FIM bundle, informed by stakeholder interviews and secondary analysis of prior FIM trials; (2) an evaluation of the efficacy of the adapted FIM implementation bundle in improving fruit and vegetable intake at 6 months among 240 patients; and (3) an assessment of implementation outcomes using the RE-AIM/PRISM framework. This proposal aligns with research priorities identified by NHLBI and national strategies to integrate nutrition into clinical care, and it will leverage implementation science to guide adaptation and optimize success. The K23 award will also provide essential methodological training to support Dr. Yoo’s transition to research independence. Dr. Yoo proposes focused training in: (1) qualitative and mixed-methods research; (2) Food is Medicine science; (3) dissemination and implementation science; (4) pragmatic clinical trials; and (5) experiential health system-level science. Dr. Yoo’s experienced and highly supportive mentoring team is led by Dr. Mark Huffman (Washington University in St. Louis), with co-mentorship from Drs. Jason Wu (The George Institute for Global Health) and Thomas Kannampallil (Washington University in St. Louis). This team is further supported by key collaborators and advisors, Drs. Maddox, Goss, Tabak, and Li, who will ensure scientific success and oversee Dr. Yoo’s advanced training. Insights from this study will lay the foundation for a future multi-site R01 trial to assess Food is Medicine implementation in obesity care. This K23 award will prepare Dr. Yoo for a successful independent research career and position him as a leader in Food is Medicine to advance cardiovascular health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $103,684 )
2026	2026	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	9/3/2026	NEW	$103,684
														Subtotal = $103,684

Grand Total All Awards = $103,684

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Advancing Sustainable Obesity Care: Integrating Food is Medicine with GLP-1 Receptor Agonists

Award Number: K23HL186120

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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