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The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.

Award Number: K23HL159270
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant. - PROJECT SUMMARY This K23 project will prepare the Principal Investigator, Justin M. Canada, PhD, to develop as an independent clinical/translational researcher who is expert in a novel form of cardiopulmonary exercise stress measurement – cardiovascular magnetic resonance imaging (MRI) – to identify factors that reduce peak oxygen consumption (VO2) in patients with heart failure. Peak VO2 reflects peak exercise capacity, a prime determinant of outcomes among patients with cardiovascular disease (CVD). This noninvasive methodology does not require intravenous contrast or ionizing radiation, eliminating possible side effects among patients in poor health. It also accurately measures exercise-associated cardiac output—a fundamental contributor to overall exercise capacity—that can be targeted with therapeutic interventions to improve overall peak exercise capacity. This project is a collaborative multi-disciplinary effort among oncologists, exercise physiologists, biomedical engineers, and cardiovascular experts to address an important issue in the emerging field of cardio-oncology. The proposal focuses on patients receiving allogeneic hematopoietic stem cell transplantation (HCT) for hematologic malignancies. Treatment-associated reductions in peak VO2 can exclude candidates from life- saving HCT. Among survivors of hematologic malignancies, reduced peak VO2 is associated with impaired quality of life and elevated risk of death not related to relapse. At present, there is no reliable method to identify those at risk for these serious adverse events. In addition to a strong, supportive environment that includes international experts, the largest HCT program in Virginia, and state-of-the-art equipment co-located within the Cancer Center that serves the HCT community, the proposal is buttressed by highly supportive preliminary data and a robust career development plan for Dr. Canada. This plan provides mentored training in the translational fundamentals of MRI theory: conduct, interpretation, and MRI application in cardiovascular and cardio-oncology clinical management. This includes expertise in the technical aspects, analysis, interpretation, and utilization of an innovative exercise stress-associated cardiovascular MRI technique to discern the mechanism of reduced exercise capacity in other heart failure syndromes. This patient-oriented mentored research training plan incorporates a highly innovative technique and an excellent training environment to develop and test a methodology that identifies the causes of reductions in peak exercise capacity, a primary determinant of HCT outcomes. The outstanding mentor team will guide the Candidate’s progress in professional milestones (publications and presentations) and oversee his continued exposure to responsible conduct of research training. At completion of this K23, Dr. Canada will be well- qualified to contribute meaningfully to an emerging field of growing research interest.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $149,048 )
2026	2026	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Cardiovascular Diseases Research	000	4	3/9/2026	NON-COMPETING CONTINUATION	$149,048
														Subtotal = $149,048

Issue Date FY: 2025 ( Subtotal = $149,048 )
2025	2025	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Cardiovascular Diseases Research	000	3	1/24/2025	NON-COMPETING CONTINUATION	$149,048
														Subtotal = $149,048

Issue Date FY: 2024 ( Subtotal = $149,049 )
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Cardiovascular Diseases Research	000	2	1/29/2024	NON-COMPETING CONTINUATION	$149,049
														Subtotal = $149,049

Issue Date FY: 2023 ( Subtotal = $149,042 )
2023	2023	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Cardiovascular Diseases Research	000	1	2/17/2023	NEW	$149,042
														Subtotal = $149,042

Grand Total All Awards = $596,187

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The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.

Award Number: K23HL159270

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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