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Implementing Prevention of Venous Thromboembolism for Ambulatory Patients with Cancer (PREVenT-APC)

Award Number: K23HL157758
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/24/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Implementing Prevention of Venous Thromboembolism for Ambulatory Patients with Cancer (PREVenT-APC) - PROJECT SUMMARY Background: Venous thromboembolism (VTE) is one of the most common causes of death in cancer patients. Guidelines recommend the use of VTE risk-stratification to identify ambulatory patients with cancer at high-risk of VTE who may benefit from primary VTE prevention with prophylactic anticoagulation. However, our preliminary data suggest that VTE risk assessment and primary prophylaxis are substantially underused. Aims and Methods: The overall objective of this project is to develop a feasible, effective, and sustainable implementation strategy to promote the uptake into clinical practice of evidence-based guidelines for VTE prevention in patients with cancer. The Specific Aims of this proposal are to: Aim 1: Conduct formative research to develop an implementation strategy (PREVenT-APC) promoting the uptake in clinical practice of a guideline-recommended, risk-based approach to primary VTE prevention for ambulatory patients with cancer; Aim 2: Using a randomized trial, assess effectiveness of the refined PREVenT-APC strategy as compared with usual care, to start and maintain thromboprophylaxis for identified high-risk patients with cancer; and Aim 3: Explore implementation outcomes and the contextual factors associated with variability in adoption, fidelity, effectiveness, and acceptability of the PREVenT-APC implementation strategy. To carry out the study, I will develop the PREVenT-APC strategy and conduct usability testing to refine the strategy (Aim 1); test the PREVenT-APC strategy via a randomized trial (Aim 2); and, using mixed methods, evaluate additional implementation outcomes, and explore variability in outcomes of the PREVenT-APC strategy (Aim 3). Career Development and Future Work: Through the objectives of the K23 Mentored Career Development Award, I will acquire advanced knowledge and apply skills in mixed method research, behavioral intervention clinical trial design, and dissemination and implementation science, which will further my goal of becoming an independent physician scientist with expertise in developing, implementing, and evaluating strategies to improve cross-specialty hematology care. The study findings will serve as a foundation for future R-level proposals to tailor and test adaptations and dissemination of the PREVenT-APC implementation strategy in different settings. Ultimately, the long-term goal of the proposed research is to reduce VTE and improve outcomes for patients with cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $164,678 )
2026	2026	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Blood Diseases and Resources Research	000	5	7/24/2026	NON-COMPETING CONTINUATION	$164,678
														Subtotal = $164,678

Issue Date FY: 2025 ( Subtotal = $165,794 )
2025	2025	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Blood Diseases and Resources Research	001	4	8/1/2025	NON-COMPETING CONTINUATION	$165,794
2025	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Blood Diseases and Resources Research	000	2	2/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $165,794

Issue Date FY: 2024 ( Subtotal = $166,323 )
2024	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Blood Diseases and Resources Research	002	3	8/13/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2024	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Blood Diseases and Resources Research	001	3	8/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$166,323
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Blood Diseases and Resources Research	000	2	8/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $166,323

Issue Date FY: 2023 ( Subtotal = $166,998 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Blood Diseases and Resources Research	000	2	7/14/2023	NON-COMPETING CONTINUATION	$166,998
														Subtotal = $166,998

Issue Date FY: 2022 ( Subtotal = $167,003 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Blood Diseases and Resources Research	000	1	7/5/2022	NEW	$167,003
														Subtotal = $167,003

Grand Total All Awards = $830,796

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Implementing Prevention of Venous Thromboembolism for Ambulatory Patients with Cancer (PREVenT-APC)

Award Number: K23HL157758

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/24/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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