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Longitudinal trajectories of early childhood respiratory symptomatology and their impact on behavioral development

Award Number: K23HD088695
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Project Summary This application for a K23 mentored career development award integrates structured career mentorship and in- depth research training with a detailed research plan is designed to foster the career as an independent investigator of Jonathan S Litt, MD, MPH, ScD is a neonatologist at Beth Israel Deaconess Medical Center and Instructor of Pediatrics at Harvard Medical School. At the completion of the award period, Dr. Litt achieved a high level of methodological expertise in advanced data collection and analytic techniques and their application to the intersecting trajectories of chronic respiratory ailments and developmental comorbidities and developing interventions aimed at improving functional outcomes in high-risk populations. Dr. Litt's career development plan involves training in 1) using large data sets to develop and test hypotheses, 2) managing patient-oriented research with large cohorts, and 3) using advanced methods for longitudinal trajectory analysis. The overarching scientific aim of this K23 award proposal is to elucidate the relationship between the development of chronic respiratory disease (wheezing, asthma) and behavioral problems in a clinical sample of high-risk preterm (PT) infants with chronic lung disease (CLD) and a large population-based birth cohort. Understanding this relationship will help inform the content and timing of targeted interventions to decrease functional morbidities and prevent disabilities, particularly in high-risk populations. Aim 1 is to assess the longitudinal relationship between wheezing-related respiratory status and behavior problems in healthy term-born children. Aim 2 is to describe the emergence and trajectory of respiratory symptoms in among PT infants with CLD. The findings of the proposed studies will fill key gaps in understanding of how physical health and behavioral functioning interact over time and inform the timing, suggest content of interventions for reducing morbidities associated with chronic disease in childhood and provide the basis for an R01 grant. Following the K23 award period, Dr. Litt will be well-positioned to apply for further federal funding as an independent investigator to develop test evidence-based interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$16,428 )
2025	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	5	11/19/2024	NON-COMPETING CONTINUATION	-$16,428
														Subtotal = -$16,428

Issue Date FY: 2022 ( Subtotal = $151,102 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	5	7/12/2022	NON-COMPETING CONTINUATION	$151,102
														Subtotal = $151,102

Issue Date FY: 2021 ( Subtotal = $151,102 )
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	4	6/14/2021	NON-COMPETING CONTINUATION	$151,102
														Subtotal = $151,102

Issue Date FY: 2020 ( Subtotal = $150,982 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	3	6/25/2020	NON-COMPETING CONTINUATION	$0
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	6/18/2020	NON-COMPETING CONTINUATION	$150,982
														Subtotal = $150,982

Issue Date FY: 2019 ( Subtotal = $150,236 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	2	6/6/2019	NON-COMPETING CONTINUATION	$150,236
														Subtotal = $150,236

Issue Date FY: 2018 ( Subtotal = $150,193 )
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	6/22/2018	NEW	$150,193
														Subtotal = $150,193

Grand Total All Awards = $737,187

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Longitudinal trajectories of early childhood respiratory symptomatology and their impact on behavioral development

Award Number: K23HD088695

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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