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Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma

Award Number: K23ES029105
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/10/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2023

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Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma - Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma. Particulate matter (PM) is a criteria pollutant, and exposures have been linked with acute and chronic health effects, including respiratory morbidity and mortality. The smallest form of PM, ultrafine PM (UFP), enters and disperses freely in the lungs, and can translocate into the bloodstream. Because of their small size, UFPs have an enormously large surface area:particle mass ratio and carry adsorbed toxic contaminants known to incite inflammatory and oxidative stress responses. They are hypothesized to be among the most harmful components of PM to human health, and yet few epidemiologic investigations have been completed due to limitations in monitoring capabilities only recently overcome. Furthermore, the sources of these particles are often unique, and indoor exposures (i.e. cooking, heating, environmental tobacco smoke) contribute heavily to individual exposure. Dr. Brigham, Assistant Professor in Pulmonary and Critical Care Medicine at Johns Hopkins University, has a strong interest in the effects of these particles on respiratory disease. She has extensive research experience in epidemiologic studies of asthma health and metabolic risk factors for asthma morbidity in both adult and pediatric populations, and conducts her research within a group combining resources from the Johns Hopkins School of Medicine and adjacent Bloomberg School of Public Health with the expertise to support indoor UFP monitoring. Dr. Brigham's proposal seeks to define the impact of indoor UFP exposure on children with asthma in Baltimore City, a uniquely susceptible population with a historically disproportionate burden of indoor air pollution and more than twice the national average of prevalent asthma. She proposes to investigate: (Aim 1) the effects of UFP exposure on pediatric asthma symptoms, lung function, and rescue-inhaler use, (Aim 2) the effects of UFP exposure on airway and systemic markers of oxidative stress and inflammation, and (Aim 3) mediation of the effects of UFP exposure on asthma health by additional modifiable metabolic factors known to affect response to larger PM: adiposity and dietary intake of omega-3 fatty acids. This award will not only provide an outstanding training vehicle for Dr. Brigham's development into an independent, NIH funded patient-oriented researcher, poised for leadership in investigations at the intersection of air pollution, metabolism, and respiratory health, but will also provide critically novel data regarding the impact of indoor UFP exposure in this vulnerable pediatric population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$795 )
2024	2022	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Environmental Health	000	4	8/5/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$795
														Subtotal = -$795

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Environmental Health	001	4	11/30/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$98,200
2023	2021	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Environmental Health	000	3	11/30/2022	NON-COMPETING CONTINUATION	-$98,200
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $163,687 )
2022	2022	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC			CAN	Environmental Health	001	4	2/10/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$163,687
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Environmental Health	000	3	2/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $163,687

Issue Date FY: 2021 ( Subtotal = $198,236 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Environmental Health	000	3	12/1/2020	NON-COMPETING CONTINUATION	$198,236
														Subtotal = $198,236

Issue Date FY: 2020 ( Subtotal = $196,677 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Environmental Health	000	2	12/23/2019	NON-COMPETING CONTINUATION	$196,677
														Subtotal = $196,677

Issue Date FY: 2019 ( Subtotal = $196,761 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Environmental Health	000	1	12/12/2018	NEW	$196,761
														Subtotal = $196,761

Grand Total All Awards = $754,566

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Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma

Award Number: K23ES029105

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/10/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2023

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