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Understanding the Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control

Award Number: K23DK120517
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 07/30/2025

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Understanding the Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control - PROJECT SUMMARY/ABSTRACT Binge-eating disorder (BED) is characterized by recurrent episodes of binge eating (uncontrolled consumption of large amounts of food in a short time period). BED is the most prevalent eating disorder in the U.S. and globally, and it is associated with significant psychosocial impairment, and psychiatric and physical morbidity. However, even with the most efficacious treatments, a substantial proportion of those with BED do not experience good outcomes. Elucidating the biobehavioral mechanisms of binge eating is critical to gaining better understanding of treatments’ effects and why they vary. In this vein, converging evidence suggests that negative affect plays a significant role in binge eating in BED, but the link between negative affect and binge eating behavior, including its neurobiological mechanisms, is not well understood. In contrast, a growing body of literature suggests that stressors tend to increase preference for highly palatable food in the general population, and that this phenomenon may involve mechanisms of increased food reward and decreased cognitive control. Thus, the goal of the K23 research project is to examine whether stressors have greater effects on (palatable) food choice and related blood oxygenation level dependent activity in young women with BED, and whether these stressor-related effects relate to real-world binge eating behavior. Dovetailing with the research aims, the K23 will provide training and mentored research experience in the following areas critical to achieving the candidate’s long-term career goal of becoming an independent clinical investigator focused on understanding the mechanisms underlying binge eating, with the ultimate goal of developing more tailored and efficacious interventions: (1) neuroscience and neuroimaging; (2) the study of stressors and their effects; (3) assessment of real-world stressors, affect, and eating; (4) responsible conduct of research; and (5) general career development. To achieve these training goals, the candidate will attend relevant classes, seminars, and scientific conferences and receive mentoring and training from an expert team including Dr. Diego Pizzagalli (Primary Mentor), Drs. James Hudson and Shelly Greenfield (Co-Mentors), and Drs. Lisa Nickerson, Joanna Steinglass, Marian Tanofsky-Kraff, & Stephen Wonderlich (Advisors). The research and training will occur at McLean Hospital, a psychiatric teaching hospital with a state-of-the-art imaging center and eating disorder research program. McLean, an affiliate of Harvard Medical School, provides an ideal environment due to its clear institutional commitment to research and academic/professional training and its unique opportunities for diverse clinical and basic researchers to collaborate to better understand the brain in illness and health. In addition to providing the candidate essential training in designing and implementing patient-oriented research with sophisticated behavioral and neurobiological measures, the K23 award will provide novel data on the role of stressors and negative affect in BED. This line of research can yield critical information relevant to developing more efficacious interventions for BED, a compelling target for improving public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$8,081 )
2026	2022	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	3/16/2026	NON-COMPETING CONTINUATION	-$8,081
														Subtotal = -$8,081

Issue Date FY: 2022 ( Subtotal = $387,552 )
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/26/2022	NON-COMPETING CONTINUATION	$194,217
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/29/2022	SUPPLEMENT FOR EXPANSION	$193,335
														Subtotal = $387,552

Issue Date FY: 2021 ( Subtotal = $194,217 )
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/26/2021	NON-COMPETING CONTINUATION	$194,217
														Subtotal = $194,217

Issue Date FY: 2020 ( Subtotal = $194,217 )
2020	2020	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/24/2020	NON-COMPETING CONTINUATION	$194,217
														Subtotal = $194,217

Issue Date FY: 2019 ( Subtotal = $194,217 )
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/24/2019	NON-COMPETING CONTINUATION	$194,217
														Subtotal = $194,217

Issue Date FY: 2018 ( Subtotal = $194,217 )
2018	2018	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/13/2018	NEW	$194,217
														Subtotal = $194,217

Grand Total All Awards = $1,156,339

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Understanding the Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control

Award Number: K23DK120517

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 07/30/2025

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