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Sarcopenia as a Predictor of Hospital-Associated Disability in Older Adults

Award Number: K23AG058756
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Sarcopenia as a Predictor of Hospital-Associated Disability in Older Adults - PROJECT SUMMARY/ABSTRACT The overall goal of this K23 mentored career development proposal is to support Dr. James Andrews’ development as an independent, patient-oriented researcher studying the contribution of sarcopenia to hospital-associated physical disability among older adults. Dr. Andrews is an Acting Assistant Professor in the Division of Rheumatology at the University of Washington (UW). Conducting the activities proposed in this application will facilitate Dr. Andrews’ training goals of gaining hands-on experience with geriatrics patient- oriented research on clinical outcomes of acute illness, learning advanced skills in key areas (Epidemiology/Biostatistics, body composition/sarcopenia assessment, skeletal muscle metabolism), and establishing a research program examining functional outcomes of acute illness in older adults. The proposed project builds upon Dr. Andrews’ experiences studying disability in rheumatic and non-rheumatic populations and his skills in clinical outcomes research; and it leverages UW’s world-class investigators, facilities, and mentorship opportunities to allow Dr. Andrews to achieve his goal of being an independent clinical investigator. This project’s primary research objective is to test the central hypothesis that sarcopenia is a risk factor for hospital-associated activity of daily living (ADL) disability among older adults. Half of all physical disability in older adults arises in the setting of hospitalization. Aging-related sarcopenia strongly predicts long-term functional outcomes (e.g. ADL disability, death) in older adults, but the relationship between sarcopenia and hospital-associated disability is unknown. Establishing sarcopenia as a risk factor for hospital-associated disability in older adults is a critical first step in understanding pathogenesis, identifying key effect modifiers and the most at-risk individuals, and ultimately developing novel interventions to prevent hospital-associated disability for the approximately 50 million older adults hospitalized each year in the United States. Aim 1 leverages the NIA-funded Health ABC dataset to identify sarcopenia (lean muscle mass and grip strength) as a risk factor for hospital-associated ADL disability among adults aged ≥ 70 years. Aim 2 & 3 will develop an original cohort of older adults hospitalized with sepsis to identify 1.) lean mass and grip strength and 2.) serum measures of skeletal muscle metabolism as predictors of hospital-associated ADL outcomes. The proposed aims will be among the first to examine aging-related sarcopenia as a risk factor for hospital-associated ADL disability in older adults and to expose mechanism of skeletal muscle metabolism with therapeutic potential. Combined with an outstanding mentorship team and a rigorous training plan, this project will prepare Dr. Andrews’ to successfully obtain R01 funding to test novel sarcopenia-targeted interventions to prevent hospital-associated ADL disability among older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	5	10/27/2024	NON-COMPETING CONTINUATION	-$69,940
2025	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	003	6	10/27/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$321,240
2025	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	5	10/27/2024	SUPPLEMENT FOR EXPANSION	-$187,920
2025	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	4	10/27/2024	NON-COMPETING CONTINUATION	-$63,380
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = -$2,842 )
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	007	5	7/12/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	008	6	7/22/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$116,110
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	005	5	6/3/2024	SUPPLEMENT FOR EXPANSION	$187,920
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	5	5/28/2024	SUPPLEMENT FOR EXPANSION	-$187,920
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	5	5/28/2024	NON-COMPETING CONTINUATION	-$188,892
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	006	5	7/11/2024	NON-COMPETING CONTINUATION	-$118,952
2024	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	004	5	6/3/2024	NON-COMPETING CONTINUATION	$188,892
2024	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	003	4	6/3/2024	NON-COMPETING CONTINUATION	$63,380
2024	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	4	5/28/2024	NON-COMPETING CONTINUATION	-$63,380
														Subtotal = -$2,842

Issue Date FY: 2022 ( Subtotal = $376,812 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	5	6/1/2022	SUPPLEMENT FOR EXPANSION	$187,920
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	5	5/11/2022	NON-COMPETING CONTINUATION	$188,892
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	5	6/14/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $376,812

Issue Date FY: 2021 ( Subtotal = $188,892 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	4	4/27/2021	NON-COMPETING CONTINUATION	$188,892
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	3	10/20/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $188,892

Issue Date FY: 2020 ( Subtotal = $648,241 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	003	3	9/8/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	3	4/10/2020	NON-COMPETING CONTINUATION	$188,892
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	3	9/4/2020	SUPPLEMENT FOR EXPANSION	$198,244
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	3	7/30/2020	SUPPLEMENT FOR EXPANSION	$261,105
														Subtotal = $648,241

Issue Date FY: 2019 ( Subtotal = $188,113 )
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	2	4/18/2019	NON-COMPETING CONTINUATION	$188,113
														Subtotal = $188,113

Issue Date FY: 2018 ( Subtotal = $187,777 )
2018	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	1	7/31/2018	NEW	$187,777
														Subtotal = $187,777

Grand Total All Awards = $1,586,993

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Sarcopenia as a Predictor of Hospital-Associated Disability in Older Adults

Award Number: K23AG058756

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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