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Adolescent Markers of Depression and the Impact of Alcohol Use

Award Number: K23AA026869
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2019
PERIOD OF PERFORMANCE END DATE: 09/30/2025

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Adolescent Markers of Depression and the Impact of Alcohol Use - PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the NCANDA consortium in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and data from a longitudinal study conducted by the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) to address one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide hands-on training in advanced longitudinal analyses of associated data. NCANDA data is already available to begin addressing central questions of the proposal. At Year 1 or 2, clinically significant depression has been identified in 61 participants after a healthy prior year following a non- depressed baseline. Also identified are those using moderate or heavy alcohol use at baseline, year 1, and year 2 of the study in 164, 223 and 283 participants, respectively. Year 3 data will be available January 2018. The K23 research specific aims are: (Aim 1) to identify whether any adolescent alcohol use is more likely to lead to long-term depression, or if long-term depression is seen more often after subsequent increases in alcohol use, or both, using latent difference score models to distinguish cause and effect. The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents, and (Aim 2) to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	5	5/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $280,518 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	5	9/7/2023	SUPPLEMENT FOR EXPANSION	$76,409
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	5	6/1/2023	NON-COMPETING CONTINUATION	$204,109
														Subtotal = $280,518

Issue Date FY: 2022 ( Subtotal = $204,109 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	4	6/1/2022	NON-COMPETING CONTINUATION	$204,109
														Subtotal = $204,109

Issue Date FY: 2021 ( Subtotal = $204,109 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	3	6/17/2021	NON-COMPETING CONTINUATION	$204,109
														Subtotal = $204,109

Issue Date FY: 2020 ( Subtotal = $204,109 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	2	6/4/2020	NON-COMPETING CONTINUATION	$204,109
														Subtotal = $204,109

Issue Date FY: 2019 ( Subtotal = $143,353 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	1	5/27/2019	NEW	$121,015
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	1	6/7/2019	NEW	$22,338
														Subtotal = $143,353

Grand Total All Awards = $1,036,198

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Adolescent Markers of Depression and the Impact of Alcohol Use

Award Number: K23AA026869

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2019

PERIOD OF PERFORMANCE END DATE: 09/30/2025

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