The need to develop children's environmental health (CEH) clinician-scientists focused on the translation of
pediatric and reproductive environmental health is critical. In parallel to the rise of developmental origins of
health and disease (DOHaD) principles, precision medicine (PM) has emerged as the new approach in
healthcare. PM seeks to transform medical care and disease prevention by identifying factors that more
reliably predict individual risk for disease but has focused almost solely on genetics, even though environment
is clearly a very large piece of the puzzle. With DOHaD principles suggesting that early life environment is at
the root of most chronic diseases, a life course perspective to PM and pediatrics is needed to understand how
human health is shaped by fetal and early childhood environments. Adverse health outcomes result from a
multitude of environmental, social and microbial toxin-induced shifts in molecular, cellular, and physiological
states and their interacting systems. Elucidating and translating the role of environment in health and
development requires specific expert training. Mount
training
Institute
(PEHSU)
ecosystem
Sinai has long been at the forefront of CEH clinical
through the longest running pediatric environmental health fellowship program in the country, an
for Exposomic Research, a P30 Core Center, a Pediatric Environmental Health Specialty Unit
and a state run CEH clinical center. We are uniquely poised to leverage this well-established
to continue to build national capacity in translational CEH through this exciting K12 program.Our
program strives to advance a systematic plan to integrate environmental health into reproductive and pediatric
PM initiatives to better address the root causes of disease. Many things are needed to realize this vision, but
one of the most pressing is building the pediatric/perinatal translational workforce needed to lead this paradigm
shift. Translation to better health outcomes will require developing broadly trained child health practitioners
able to engage in transdisciplinary (TD) teams that extend beyond discipline-specific concepts, approaches,
and methods. We seek to establish the Mount Sinai program for Scholars in Environmental Pediatrics,
Reproductive Health, and Life Course Science embedded in a mature TD team science learning culture
grounded in the principle that the major proportion of the variability in health outcomes is environmentally
driven. This program will be led by environmental health physician-scientists and leverages Mount Sinai's
longstanding commitment to CEH, our Region 2 PEHSU, our NY state children's environmental health centers,
our established pipeline programs and regional networks to identify potential scholars, our infrastructure in
pediatric/perinatal environmental health research and workforce development, and our institutional
investments in exposomics. Our K12 program will develop healthcare professionals poised to integrate
environmental science with established PM and pediatric care efforts and develop the next generation of
versatile children's environmental health leaders.