Tuesday, February 17, 2026 2/17/2026

Syndecan-1 regulation of lung fibrosis

Award Number: K08HL141590
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/05/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

Group Awards By:

View Award Description

Syndecan-1 regulation of lung fibrosis - ABSTRACT This proposal is for the career development of Tanyalak Parimon, M.D., into an independent physician-scientist focused on basic/translational research in lung fibrosis. The PI will have as co-mentors Peter Chen, M.D., who has an established research program in the lung biology of syndecan-1 and Dolores Di Vizio, M.D., Ph.D., who is a leading expert in extracellular vesicle biology. The comprehensive training program will include laboratory- based research, didactic lectures, coursework and workshop, grantsmanship, scientific conferences (internal and external), and career guidance by a scientific advisory committee that includes the co-mentors. With this proposal, I will have the opportunity to continue to learn and broaden my research skills and knowledge of mechanisms of lung injury and repair with a focus in lung fibrosis and extracellular vesicle (EVs) biology. Additionally, I will leverage the scientific and technical knowledge of leading respiratory research and EVs experts at Cedars-Sinai and the greater Los Angeles area in performing my research and in my training to become an independent physician-scientist. For the research proposal, I will be furthering our understanding into mechanisms of lung fibrosis pathogenesis with the long-term goal to identify the cellular target(s) for a novel therapeutic option for lung fibrosis and to become a leading independent investigator in this field. Syndecan-1, a transmembrane heparan sulfate proteoglycan primarily expressed on epithelial cells, has extensive roles in epithelial cells injury and repair, and I show that it has a central role in lung fibroproliferative diseases. The mechanism that I will explore and is supported by my preliminary data is that syndecan-1 altered the miRNA profile within extracellular vesicles (EVs) secreted by the alveolar epithelial type II cells (AECII) to promote fibrogenic changes within the lung microenvironment. These findings led to the hypothesis that syndecan-1 promotes lung fibrosis by controlling anti-fibrotic miRNAs packaging in EVs, thereby reshaping the lung microenvironment to promote fibroproliferation. Under this career development award, I propose to test the hypothesis with three specific aims: 1) Identify mechanisms by which syndecan-1 regulates miRNA packaging into EVs; 2) Elucidate how syndecan-1 facilitates fibrosis by promoting AECII senescence; and 3) Evaluate how syndecan-1 controls fibrotic epithelial-derived EVs to augment fibroproliferation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	5	2/6/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $170,748 )
2024	2024	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	5	6/14/2024	NON-COMPETING CONTINUATION	$170,748
														Subtotal = $170,748

Issue Date FY: 2023 ( Subtotal = $170,748 )
2023	2023	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	4	7/20/2023	NON-COMPETING CONTINUATION	$170,748
														Subtotal = $170,748

Issue Date FY: 2022 ( Subtotal = $170,748 )
2022	2022	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	3	6/6/2022	NON-COMPETING CONTINUATION	$170,748
														Subtotal = $170,748

Issue Date FY: 2021 ( Subtotal = $170,748 )
2021	2021	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	2	6/18/2021	NON-COMPETING CONTINUATION	$170,748
														Subtotal = $170,748

Issue Date FY: 2020 ( Subtotal = $170,748 )
2020	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Lung Diseases Research	000	1	7/5/2020	NEW	$170,748
														Subtotal = $170,748

Grand Total All Awards = $853,740

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Syndecan-1 regulation of lung fibrosis

Award Number: K08HL141590

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/05/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer