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Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta

Award Number: K08ES038232
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta - Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta Project Summary/Abstract: Micro and nanoplastics (MNPs), are increasingly pervasive in our environment. Microplastics are typically defined as plastic particles smaller than 5 millimeters (5mm), while nanoplastics are even smaller, measuring less than 1 micrometer (1 µm) Originating from the degradation of plastic materials entering our landfills, oceans, and water sources, micro and nanoplastics pose significant concerns for human health. Recent research has expanded its focus on investigating the interactions between microplastics and human placenta, with the understanding of the pivotal role that the placenta has in fetal health and development. This study introduces a groundbreaking perspective aimed at addressing the substantial knowledge gap present about how microplastics translocate into placental tissue and the critical role that chylomicrons may have in facilitating this process. The working hypothesis is that chylomicron-mediated microplastic uptake compromises placental barrier function, leading to the accumulation of microplastics within the placenta and ultimately alters barrier function and cellular response. Utilizing state-of-the-art quantitative methods in previous studies, we have established that the average human placenta at full term contains 130ug/g of total plastics, predominantly comprising polyethylene (53%), polyvinylchloride (10%), and nylon (8.7%). The combination of the prior and this proposed study promises to significantly advance our understanding of the intricate interactions of microplastics, placental function, and fetal development. By gaining a broader understanding of the crucial role of chylomicrons in facilitating microplastic uptake and the consequences, thereof, this research will guide how potential mitigation of microplastic contamination may play a role on maternal and fetal health outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $167,928 )
2026	2026	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Environmental Health	000	1	3/31/2026	NEW	$167,928
														Subtotal = $167,928

Grand Total All Awards = $167,928

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Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta

Award Number: K08ES038232

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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