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Geographic Variation in Non-HCC MELD Exceptions and Its Effect on Liver Transplant Waitlist Outcomes

Award Number: K08DK125769
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Geographic Variation in Non-HCC MELD Exceptions and Its Effect on Liver Transplant Waitlist Outcomes - Summary: Geographic variation in model for end stage liver disease (MELD) scores at transplant across donation service areas has fueled a major policy debate over allocation of donor livers. An important caveat to this perceived disparity is the focus on allocation MELD, in which patients with lower calculated MELD scores may be assigned a higher score if their calculated MELD is thought to underestimate the risk of waitlist mortality. Analysis of calculated MELD at transplant demonstrates much less variation between regions. Some high allocation MELD regions actually have low calculated MELD scores relative to the rest of the country. The different pictures painted by allocation versus calculated MELD scores highlight the critical role MELD exception points play in geographic differences in access to transplantation. A national liver review board was recently implemented to impose national standardization of MELD exception scores in an effort to mitigate geographic disparity. A potential flaw in this strategy is the assumption that the risk of mortality associated with a given MELD score or exception diagnosis is the same across geographic areas. We know that social determinants of health and access to care vary widely across the country, however, and that these differences have a significant impact on health outcomes. Imposing a geographically uniform MELD exception scoring policy that does not account for these important differences may have the unintended effect of overestimating the risk of waitlist mortality for exception patients in some regions while underestimating that risk in others, thus worsening geographic disparity rather than mitigating it. I hypothesize that significant geographic variation exists in the prevalence and appropriateness of MELD exceptions scores at the county level, and that appropriate adjustment to MELD exception scores based on a candidate’s location will mitigate geographic disparity in liver transplant waitlist mortality. Despite abundant literature on geographic disparity in liver transplantation, few studies actually apply formal geospatial analysis to geographically based questions facing the field. I propose to utilize such techniques to accomplish the following unique aims: (1) determine the prevalence and appropriateness of MELD exceptions on a county level and diagnose the presence of geographic clusters where these exceptions provide an inappropriate advantage to transplant candidates with MELD exception scores; (2) determine adjusted MELD exception scores which would equalize waitlist mortality risk between exception and non-exception patients in each geographic area; and (3) simulate waitlist outcomes under an alternative allocation scenario where MELD exception points are assigned according to geographic region as determined in Aim 2. This study will provide a more granular and personalized approach to the estimation of waitlist mortality. The mentoring and training afforded by this award will foster my growth as an investigator by allowing me to focus on building an expertise in geospatial analysis and advanced simulation, advancing my long-term career goal of research independence as a surgeon-scientist with R01 funding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $161,657 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/28/2025	NON-COMPETING CONTINUATION	$161,657
														Subtotal = $161,657

Issue Date FY: 2024 ( Subtotal = $161,657 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	3/29/2024	NON-COMPETING CONTINUATION	$161,657
														Subtotal = $161,657

Issue Date FY: 2023 ( Subtotal = $161,307 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	3/21/2023	NON-COMPETING CONTINUATION	$161,307
														Subtotal = $161,307

Issue Date FY: 2022 ( Subtotal = $160,775 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/29/2022	NON-COMPETING CONTINUATION	$160,775
														Subtotal = $160,775

Issue Date FY: 2021 ( Subtotal = $161,597 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	5/12/2021	NEW	$161,597
														Subtotal = $161,597

Grand Total All Awards = $806,993

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Geographic Variation in Non-HCC MELD Exceptions and Its Effect on Liver Transplant Waitlist Outcomes

Award Number: K08DK125769

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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