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GLUCAGON REGULATION BY A NOVEL BROWN ADIPOSE FACTOR

Award Number: K08DK115795
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/15/2017
PERIOD OF PERFORMANCE END DATE: 12/14/2023

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GLUCAGON REGULATION BY A NOVEL BROWN ADIPOSE FACTOR - Project Summary / Abstract This proposal aims to develop the applicant into an independent physician-scientist in the field of diabetes and metabolism. The principal investigator Dr. Jing Hughes has undergone PhD training in the basic biological sciences and completed clinical training in internal medicine and the endocrinology subspecialty. The proposed 5-year career development plan will build on Dr. Hughes's experiences in endocrinology and provide her with further expertise in the design and conduct of basic diabetes research. Dr. Hughes's long-term goal is to establish an independent laboratory dedicated to studying islet biology, with a goal to discover new endocrine and paracrine pathways modulating islet hormone secretion. The central guidance and training environment for this project will be provided by the mentor, Dr. David W. Piston, who is the Chair of Cell Biology at Washington University, also a recognized leader in islet physiology and imaging expert. Dr. Piston has an excellent track record for training physician-scientists, especially at the incipient stages of their careers. In addition to Dr. Piston's mentoring, Dr. Hughes will be able to take advantage of the rich resources available at Washington University, including scientific as well as career guidance from her faculty advisory committee and collaborators. The research set forth herein seeks to address how brown fat restores glucose balance by modulating glucagon secretion in diabetic animals. In the past few years, the Piston laboratory has revolutionized thinking about islet physiology by demonstrating new and unexpected roles in diabetes modulation by alpha cell hormones. We now examine the mechanism by which factors secreted by brown adipose tissue act on alpha cells to regulate glucagon production, a phenomenon that has never before been investigated. Dr. Hughes will use a proteomics strategy to identify the brown adipose factor and test the hypothesis that its effect on glucagon suppression is mediated through GPCRs on islet cells. The proposed studies have the potential to provide proof-of-principle for novel translational treatments and reduce suffering from diabetes. This K08 mentored research award will provide the necessary resources for Dr. Hughes to complete these studies and to develop the necessary intellectual foundation and skill set as an independent diabetes investigator.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $160,871 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	12/10/2021	NON-COMPETING CONTINUATION	$160,871
														Subtotal = $160,871

Issue Date FY: 2021 ( Subtotal = $160,871 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	12/7/2020	NON-COMPETING CONTINUATION	$160,871
														Subtotal = $160,871

Issue Date FY: 2020 ( Subtotal = $214,871 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/12/2019	NON-COMPETING CONTINUATION	$160,871
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	8/19/2020	SUPPLEMENT FOR EXPANSION	$54,000
														Subtotal = $214,871

Issue Date FY: 2019 ( Subtotal = $115,091 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/13/2018	NON-COMPETING CONTINUATION	$115,091
														Subtotal = $115,091

Issue Date FY: 2018 ( Subtotal = $116,591 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/11/2017	NEW	$116,591
														Subtotal = $116,591

Grand Total All Awards = $768,295

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GLUCAGON REGULATION BY A NOVEL BROWN ADIPOSE FACTOR

Award Number: K08DK115795

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/15/2017

PERIOD OF PERFORMANCE END DATE: 12/14/2023

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