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Health Opportunities & Promoters to Enhance Screening for Lung Cancer (Hopes for Lung Cancer)

Award Number: K08CA270430
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/03/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Health Opportunities & Promoters to Enhance Screening for Lung Cancer (Hopes for Lung Cancer) - Candidate: This K08 Mentored Clinical Scientist Research Career Development Award describes Efrén J. Flores, MD, as a candidate well-positioned to complete the proposed training objectives and research aims. Dr. Flores’ background as a physician-scientist with experience in lung cancer screening (LCS) has focused on improving lung cancer outcomes through early detection. He has developed evidence-based interventions to increase LCS uptake among high-risk patients for lung cancer who currently smoke or quit, with a particular focus on Hispanic/Latino and other populations that, based on the literature, experience worse lung cancer outcomes due to later stage diagnosis. Background: Lung cancer remains the leading cause of cancer-specific mortality in the US due to a complex combination of factors, particularly among Hispanic/Latino communities and other populations that research has shown experience worse lung cancer outcomes due to advanced stage at presentation. Lung cancer screening (LCS) can save many lives through early detection among all eligible high-risk patients that currently smoke or quit. Without increasing efforts to improve accurate smoking status documentation and outreach interventions to promote LCS uptake the current gaps in lung cancer outcomes and mortality will persist. Study aims: Based on prior research and in alignment with the current NIH priorities of promoting research on scientifically valid, measurable health outcomes, and shifting to solution oriented research to improve gaps in care, Dr. Flores has adapted an NIH research framework incorporated elements from Ford’s evidence-based theoretical model to guide the following proposed study aims: 1) To elucidate barriers and facilitators to consistent identification and documentation of smoking status to promote LCS uptake; 2) To assess feasibility, acceptability, and reach of the digital delivery of an educational video to promote LCS uptake among Hispanic current and former smokers; 3) To explore the effect of the digital delivery of the educational video to increase interest, intent, and scheduling of LCS. Training: The career development plan will allow Dr. Flores to develop expertise in tailoring LCS interventions among LCS-eligible patients by completing training objectives in three areas: 1) mixed methods to inform health interventions; 2) community-based participatory research to guide outreach interventions; 3) digital interventions tailored to promote LCS uptake. Advanced coursework, a resource-rich environment, and the proposed research will support these objectives. Mentorship: A team of expert mentors, including Dr. Elyse R. Park (primary mentor),Dr. Ruth C. Carlos and Dr. Kelly E Irwin (co-mentors), and scientific advisors Dr. Jennifer Haas, Dr. Nancy Rigotti, Dr. Giselle Perez, Dr. Jo-Anne Shepard, Dr. Joseph Betancourt, and Dr. Nathaniel Mercaldo will guide Dr. Flores’ training and research duration of the award. Impact: The successful completion of this proposal will provide Dr. Flores with rigorous training and research expertise that will be foundational for his subsequent NCI R01 as a leading independent investigator developing novel outreach interventions focused on improving lung cancer outcomes through early detection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $252,700 )
2026	2026	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Cancer Research Manpower	000	4	2/4/2026	NON-COMPETING CONTINUATION	$252,700
														Subtotal = $252,700

Issue Date FY: 2025 ( Subtotal = $280,777 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Cancer Research Manpower	000	3	12/19/2024	NON-COMPETING CONTINUATION	$280,777
														Subtotal = $280,777

Issue Date FY: 2024 ( Subtotal = $280,777 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Cancer Research Manpower	000	2	2/20/2024	NON-COMPETING CONTINUATION	$280,777
														Subtotal = $280,777

Issue Date FY: 2023 ( Subtotal = $280,777 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Cancer Research Manpower	000	1	2/3/2023	NEW	$280,777
														Subtotal = $280,777

Grand Total All Awards = $1,095,031

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Health Opportunities & Promoters to Enhance Screening for Lung Cancer (Hopes for Lung Cancer)

Award Number: K08CA270430

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/03/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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