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Finding Synergy with Radiation Therapy and Immunotherapy for Patients with Lung Cancer

Award Number: K08CA231454
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 12/22/2023

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Finding Synergy with Radiation Therapy and Immunotherapy for Patients with Lung Cancer - 7. PROJECT SUMMARY/ABSTRACT The proposed career development training award will provide the candidate, Dr. Bradford Perez, with an excellent opportunity to establish as an independent clinical/translational investigator. As part of his translational effort he seeks to characterize tumor infiltrating immune cells to understand mechanism of synergy with radiation and immunotherapy combinations with a specific interest and plan to further evaluate anti-41bb therapy in conjunction with radiation therapy. An improved understanding of this mechanism is critical to robust and successful implementation of combined modality strategies in the clinic. The work proposed as part of this award application will also allow Dr. Perez to grow and establish independence as a clinical investigator. He currently serves as the principal investigator for an ongoing investigator initiated clinical trial for patients with extensive stage small cell lung cancer. With the support of a strong mentorship team, he was able to draft the protocol and navigate the necessary regulatory infrastructure to enroll patients on this Phase I/II trial. The human tissue samples (serial peripheral blood and tumor samples) collected as part of this ongoing trial will be thoroughly analyzed as part of Research Aim 2 to help understand the precise mechanism by which RT modulates the immune system. Through an improved understanding, future clinical studies as proposed in Research Aim 3 can be rationally designed to maximize the opportunity for synergy with radiation and immunotherapy. The application includes a robust plan that highlights Dr. Perez's limitations in prior training with a didactic program that is specifically designed overcome knowledge gaps in the fields of cancer immunity/immunotherapy and early stage clinical trial design. In working to establish independence, the final training aim includes dedicated career development focus on grant writing and publications. This training will help Dr. Perez to master the necessary skills crucial to success as an independent investigator. Drs. Antonia, Conejo-Garcia and Schell will closely advise and oversee Dr. Perez's career development and represent a team of international experts in the field of cancer clinical and translational investigation. The proposed training in this K08 NCI Mentored Clinical Scientist training grant for patient oriented research will allow Dr. Perez to transition to an independent clinical and translational researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$346,603 )
2025	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	5	11/21/2024	NON-COMPETING CONTINUATION	$0
2025	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	002	5	12/2/2024	NON-COMPETING CONTINUATION	-$238,752
2025	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	001	4	12/2/2024	NON-COMPETING CONTINUATION	-$107,851
														Subtotal = -$346,603

Issue Date FY: 2023 ( Subtotal = $238,752 )
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	5	8/21/2023	NON-COMPETING CONTINUATION	$238,752
														Subtotal = $238,752

Issue Date FY: 2022 ( Subtotal = $238,752 )
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	001	4	7/27/2022	NON-COMPETING CONTINUATION	$238,752
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	3	11/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $238,752

Issue Date FY: 2021 ( Subtotal = $238,752 )
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	3	9/1/2021	NON-COMPETING CONTINUATION	$238,752
														Subtotal = $238,752

Issue Date FY: 2020 ( Subtotal = $238,752 )
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	2	7/31/2020	NON-COMPETING CONTINUATION	$238,752
														Subtotal = $238,752

Issue Date FY: 2019 ( Subtotal = $238,752 )
2019	2019	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Research Manpower	000	1	5/31/2019	NEW	$238,752
														Subtotal = $238,752

Grand Total All Awards = $847,157

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Finding Synergy with Radiation Therapy and Immunotherapy for Patients with Lung Cancer

Award Number: K08CA231454

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 12/22/2023

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