Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

From inhibitors to enzymatic deficiencies: exploring alterations in erythrocyte glycolysis as an antimalarial strategy.

Award Number: K08AI193172
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/07/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2030

Group Awards By:

View Award Description

From inhibitors to enzymatic deficiencies: exploring alterations in erythrocyte glycolysis as an antimalarial strategy. - Project Summary/Abstract The malaria parasite Plasmodium falciparum is responsible for millions of cases of malaria and over 500,000 global deaths each year. Resistance to current first-line antimalarial regimens, artemisinin-based therapies, is spreading in Southeast Asia and Africa. This continued spread threatens current malaria control and eradication efforts, and new antimalarials with novel mechanisms of action are urgently needed. All currently approved antimalarials target parasite-specific enzymes and pathways. Host-directed therapies, which target host proteins or pathways that are essential to the parasite, could serve as a novel antimalarial strategy. Determining the role of host pathways in the parasite lifecycle will inform future host-targeting antimalarial drug development. This project aims to determine the role of erythrocyte glycolysis in the Plasmodium falciparum intraerythrocytic lifecycle. In Specific Aim 1, the candidate will inhibit glycolysis in terminal erythrocytes and determine how this disruption affects P. falciparum growth, progression through the lifecycle, and susceptibility to oxidative stress. In Specific Aim 2, the candidate will use gene editing to generate pyruvate kinase-deficient erythrocytes and examine how prolonged disruptions in glycolysis affect the parasite. The results of the proposed experiments will yield a comprehensive understanding of why erythrocyte glycolysis is essential to the P. falciparum intraerythrocytic lifecycle and establish its tractability as an antimalarial target. The candidate is a pediatric infectious diseases specialist committed to studying host-parasite interactions in malaria parasites. The proposed training and research project will be conducted at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (UPenn). These two institutions are leaders in the study of host-pathogen interactions and erythrocyte biology and development and provide an ideal environment for the proposed research and career development. The candidate will be mentored by Dr. Audrey John with the support of an experienced and diverse advisory committee, including Drs. Stella Chou, Stefano Rivella, Akhil Vaidya, and Sarah Tishkoff. The candidate’s long-term goal is to develop a research program that examines host-parasite interactions in malaria infection and leverages these interactions to identify potential antimalarial targets and develop therapies. Completion of the proposed research and career development will provide a strong foundation for the candidate’s future career.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $187,056 )
2026	2026	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	2	6/30/2026	NON-COMPETING CONTINUATION	$187,056
														Subtotal = $187,056

Issue Date FY: 2025 ( Subtotal = $187,056 )
2025	2025	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	1	7/7/2025	NEW	$187,056
														Subtotal = $187,056

Grand Total All Awards = $374,112

Top

All Categories

About

Search

Reports

Data Submission

Award Information

From inhibitors to enzymatic deficiencies: exploring alterations in erythrocyte glycolysis as an antimalarial strategy.

Award Number: K08AI193172

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/07/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer