Tuesday, September 16, 2025 9/16/2025

Predicting Morbidity and Mortality for HIV-Related Opportunistic Infections

Award Number: K08AI181606
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/05/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Predicting Morbidity and Mortality for HIV-Related Opportunistic Infections - PROJECT SUMMARY This project uses machine learning to predict and improve outcomes for people with HIV (PWH). The research has been refined based on Year 1 findings, which highlighted significant regional variations in opportunistic infection (OI) patterns from the National Inpatient Sample (NIS) dataset. The project will now incorporate a national perspective to complement the original focus on the southern US. The research will predict the effects of simulated health insurance coverage expansion on OI-related hospitalizations and in-hospital mortality, using both national (NIS) and state-level (SID) data. These analyses will involve forecasting models and unsupervised machine learning to identify key trends, costs, and risk factors. Additionally, the project will develop and refine a predictive model for individual PWH clinical outcomes using the ADVANCE EMR network, with a new focus on health care access variables like insurance status and urban/rural location. The project's goal is to produce actionable risk scores and provide evidence to inform health policy, particularly regarding insurance coverage and geographic access, in alignment with national priorities for ending the HIV epidemic. The work will also focus on reusing these methods to develop open-source tools to make computational epidemiology more accessible to the broader HIV research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $191,484 )
2025	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	2	8/18/2025	NON-COMPETING CONTINUATION	$191,484
														Subtotal = $191,484

Issue Date FY: 2024 ( Subtotal = $191,484 )
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	1	8/28/2024	NEW	$191,484
														Subtotal = $191,484

Grand Total All Awards = $382,968

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Predicting Morbidity and Mortality for HIV-Related Opportunistic Infections

Award Number: K08AI181606

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/05/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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