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Developing a Chiropteran model to study the impact of thermal stress on antiviral immunity and inflammatory responses

Award Number: K01OD037645
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Developing a Chiropteran model to study the impact of thermal stress on antiviral immunity and inflammatory responses - PROJECT SUMMARY/ABSTRACT The purpose of the proposed Career Development Award (K01 SERCA) is to provide Dr. Anna Fagre with protected time and collaborative mentorship so that she can build a strong foundation for her career as an independent investigator. Dr. Fagre’s proposed K01 career development training plan builds on >7 years of experience studying bats (order Chiroptera), arthropod vectors, and arboviruses in both the field and the lab. Importantly, it integrates additional training in three focus areas: (1) development of atypical animal models for complex studies involving host-arbovirus-vector interactions, (2) advanced training in multi- omics analysis, and (3) application of comparative approaches in immunology and stress physiology to Chiropteran models of infection and disease. Dr. Fagre’s proposed K01 research outlines the development of a bat model to characterize the impacts of thermal stress on host-arbovirus-vector interactions, incorporating novel datalogging technologies to minimize animal handling while leveraging methodologies used in the fields of stress physiology and environmental health. Dr. Fagre will explore these questions with 3 specific aims: (1) development of a Chiropteran model for assessing innate immunity and inflammasome activation in bats exposed to thermal stress, (2) characterization of ambient temperature’s impact on host-vector interactions in bats following subdermal inoculation with mosquito salivary gland extract, and (3) quantification of ZIKV infection dynamics and host responses at different temperatures in cell lines derived from taxonomically diverse bat species. The anticipated results will contribute to ecoimmunology and ecophysiology studies by expanding our knowledge of how heat stress affects bat immunology and host-virus interactions. In leading these studies, Dr. Fagre will be uniquely poised to build out an independent research program interrogating the transmission dynamics of emerging arboviruses, harnessing a combination of in vivo and in vitro methods supplemented with field-based studies leveraging her past epidemiologic training. Not only will the proposed aims build a framework within which to characterize the impact of environmental stress on host-virus-vector interactions and viral infection outcomes, but results will aid in the identification of valuable diagnostic biomarkers for heat stress and viral infection. The K01 SERCA award would provide Dr. Fagre with continued funding and dedicated time to strengthen her research portfolio and build her own research program before applying for tenure-track faculty positions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $124,767 )
2025	2025	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Research Infrastructure Programs	000	2	7/2/2025	NON-COMPETING CONTINUATION	$124,767
														Subtotal = $124,767

Issue Date FY: 2024 ( Subtotal = $125,238 )
2024	2024	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Research Infrastructure Programs	000	1	6/25/2024	NEW	$125,238
														Subtotal = $125,238

Grand Total All Awards = $250,005

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Developing a Chiropteran model to study the impact of thermal stress on antiviral immunity and inflammatory responses

Award Number: K01OD037645

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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