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Promoting PrEP shared decision-making and adherence among pregnant and breastfeeding women in Zambia

Award Number: K01MH121186
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/17/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Promoting PrEP shared decision-making and adherence among pregnant and breastfeeding women in Zambia - ABSTRACT Pre-exposure prophylaxis (PrEP) is a promising tool for the prevention of HIV acquisition during pregnancy and the postpartum period and is a recommended component of a comprehensive package of prevention of mother- to-child HIV transmission services. Yet, few strategies exist to promote person-centered shared decision-making about PrEP use during pregnancy and breastfeeding despite the complexity of this decision and the importance of shared decision-making for medication adherence. The proposed training and research plan in this Mentored Research Scientist Development Award (K01) application will provide the essential training and skills that the principle investigator, Dr. Lauren M. Hill, PhD, needs to launch a productive career in PrEP decision-making research and in the development and evaluation of behavioral interventions to promote the utilization of and adherence to medicines for the prevention and treatment of HIV. Further, the research conducted throughout the course of this award would contribute meaningfully to the successful delivery of PrEP in the context of antenatal care in sub-Saharan Africa to ensure that decision-making regarding PrEP use by pregnant and breastfeeding women is person-centered to encourage appropriate and adherent use. To achieve this, Dr. Hill proposes three aims: First, she will identify values important to women’s decision-making about PrEP use during pregnancy and breastfeeding through a mixed methods formative study. Second, using this information and the results of a comprehensive needs assessment with pregnant women, their partners, and antenatal health care workers, she will develop a PrEP shared decision-making aid. Third, she will conduct a pilot trial to evaluate the effect of the shared decision-making intervention on the proximal cognitive endpoint of decisional conflict and explore the treatment effect on PrEP adherence. The training acquired by Dr. Hill through this timely study, in combination with didactic coursework, applied training, and mentorship will target the four training objectives: 1) to build expertise in medical decision-making with a focus on the development and evaluation of shared decision- making interventions; 2) to gain training in methods for the design, management, and analysis of trials to evaluate clinical interventions supporting the use of biomedical HIV prevention methods; 3) to master skills in the design of mixed methods studies and integration of mixed methods data for intervention design and evaluation; and 4) to develop the professional skills, expertise, and pilot data to facilitate her development toward research independence. Dr. Hill proposes to achieve these goals through a rigorous program of training and research to build upon and complement her training and experience in behavioral research for the primary prevention of HIV to fully prepare her for a career as an independent scientist in the field of global HIV/AIDS prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $181,247 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	5	11/17/2023	NON-COMPETING CONTINUATION	$181,247
														Subtotal = $181,247

Issue Date FY: 2023 ( Subtotal = $181,247 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	4	11/17/2022	NON-COMPETING CONTINUATION	$181,247
														Subtotal = $181,247

Issue Date FY: 2022 ( Subtotal = $181,247 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	3	11/9/2021	NON-COMPETING CONTINUATION	$181,247
														Subtotal = $181,247

Issue Date FY: 2021 ( Subtotal = $181,247 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	2	11/9/2020	NON-COMPETING CONTINUATION	$181,247
														Subtotal = $181,247

Issue Date FY: 2020 ( Subtotal = $181,247 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	001	1	12/16/2019	NEW	$0
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	002	1	5/14/2020	NEW	$0
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	1	12/14/2019	NEW	$181,247
														Subtotal = $181,247

Grand Total All Awards = $906,235

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Promoting PrEP shared decision-making and adherence among pregnant and breastfeeding women in Zambia

Award Number: K01MH121186

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/17/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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