Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

MOLECULAR MECHANISMS OF THALAMOCORTICAL DEVELOPMENT

Award Number: K01MH069647
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2004
PERIOD OF PERFORMANCE END DATE: 12/31/2008

Group Awards By:

View Award Description

MOLECULAR MECHANISMS OF THALAMOCORTICAL DEVELOPMENT - DESCRIPTION (provided by applicant): The cerebral cortex mediates perceptions and motor control by receiving and sending information through the thalamus. Some neurological disorders such as mental retardation, epilepsy, and schizophrenia appear to involve developmental defects in the wiring of the cerebral cortex. Molecular mechanisms of thalamocortical axon (TCA) development will be studied by taking a forward genetics approach. Specific Aim I: To peform a screen for mouse mutants with defects in thalamocortical development, using a specific reporter. The TCA-TLZ (thalamocortical axon-tau-lacZ) reporter line allows visualization of TCAs in whole brains without slicing, and therefore provides a unique tool with which to rapidly screen for defects in thalamocortical development. The reporter line will be mutagenized and the brains of third-generation progeny at embryonic day 18 will be analyzed for defects. Screening embryos will enable recovery of lethal mutations. This reporter will reveal defects in thalamic axon guidance and cortical lamination. Specific Aim Il: To characterize the phenotypes of mutants identified in the screen. Mutant brains will be examined at several developmental stages using the tau-lacZ marker as well as standard neuroanatomical and histological methods to determine the extent and cause of the phenotypes observed. Specific Aim Ill: To positionally clone one or two genes identified in the screen that represent the most interesting phenotypes and novel loci. After high resolution mapping, candidate genes will be examined by expression and sequencing of exons from the mutants to find the mutations. The Candidate has an excellent record so far as a neuroscientist, but wishes to receive additional training in mouse genetics before starting an independent laboratory to study the molecular mechanisms underlying cortical development. In the Ph.D., C. elegans genetics was used to study how neurons target proteins to specific membrane domains. A transition was made to the rodent system to study cortical development using histological and neuroanatomical techniques. To add mouse genetics to the skill set, the candidate has arranged to work jointly with Dr. Christopher Walsh and Dr. David Beier, both at Harvard Medical School. Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $138,171 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Mental Health Research Career/Scientist Development Awards	000	5	12/27/2007	NON-COMPETING CONTINUATION	$138,171
														Subtotal = $138,171

Issue Date FY: 2007 ( Subtotal = $135,478 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Mental Health Research Career/Scientist Development Awards	000	4	2/7/2007	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$135,478
														Subtotal = $135,478

Issue Date FY: 2006 ( Subtotal = $133,339 )
2006	2006	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Career/Scientist Development Awards	000	3	1/17/2006	NON-COMPETING CONTINUATION	$133,339
														Subtotal = $133,339

Issue Date FY: 2005 ( Subtotal = $130,628 )
2005	2005	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Career/Scientist Development Awards	000	2	12/20/2004	NON-COMPETING CONTINUATION	$130,628
														Subtotal = $130,628

Issue Date FY: 2004 ( Subtotal = $128,305 )
2004	2004	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Career/Scientist Development Awards	000	1	12/8/2003	NEW	$128,305
														Subtotal = $128,305

Grand Total All Awards = $665,921

Top

All Categories

About

Search

Reports

Data Submission

Award Information

MOLECULAR MECHANISMS OF THALAMOCORTICAL DEVELOPMENT

Award Number: K01MH069647

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2004

PERIOD OF PERFORMANCE END DATE: 12/31/2008

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer