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The SMART-CV Study: Systems Modeling Approaches to Reducing Disparities in Cardiovascular Diseases

Award Number: K01MD014163
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/16/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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The SMART-CV Study: Systems Modeling Approaches to Reducing Disparities in Cardiovascular Diseases - ABSTRACT Cardiovascular diseases (CVDs) represent the leading cause of death in the US and are costly to the nation. Despite ongoing prevention efforts, socially and economically disadvantaged populations continue to bear the highest burden of CVDs. There is growing evidence that social determinants of health can play a role in producing such disparities in CVD. Yet current interventions designed to reduce disparities in CVD seldom focus on the social determinants of cardiovascular health across multiple domains and levels of influence but tend to focus on individual-level factors. Furthermore, when designing interventions, policymakers have to consider the trade-offs between interventions that maximize health in the general population and those that minimize health disparities and failure to reach a balance between these can result in increased health disparities and suboptimal population health. Therefore, to efficiently reduce disparities in CVD—coronary heart diseases and stroke, there is a pressing need for assisting policy decision-making in the design of sustainable and affordable targeted health interventions that integrate social factors across domains and levels of influence and which targets the socially and economically disadvantaged populations. This K01 proposal will apply several analytic approaches including key informant interviews, the synthetic control method and simulation modeling and systems science (SMSS) methods to evaluate the impact and costs of intervention strategies that have the potential to efficiently reduce CVD health disparities. To carry out this proposal, Dr. Nianogo will (1) identify interventions and policies that are implemented in California which focused on the social determinants of cardiovascular health across multiple domains and levels of influence, (2) investigate the impact of three societal policy interventions on CVD incidence; (3) develop a computer simulation model to project the long-term impact and cost-effectiveness of interventions and policies targeting disadvantaged subpopulations, high-risk subpopulations. Findings from this study help identify targeted health interventions that have the potential to reduce health disparities in CVD and inform policy decision-making. This K01 proposal builds on the candidate’s previous research that developed a computer simulation model (Virtual Los Angeles Cohort—ViLA) to study the prevalence and incidence of obesity and type 2 diabetes among a representative sample of U.S. persons born in Los Angeles and followed from birth to age 65. The proposal will be pursued within the context of a strong mentorship that has adequate extensive experience and expertise on intervention research, CVDs, health disparities and simulation modeling that is necessary for the success of this project. UCLA provides an adequate environment to conduct such innovative research. Throughout this proposal, the candidate will gain skills in SMSS and CVD disparities research; these skills are critical to providing Dr. Nianogo with the means and knowledge to become a successful independent investigator in computational epidemiology and SMSS and to secure future R01 funding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $134,100 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	001	5	5/28/2024	NON-COMPETING CONTINUATION	$13,409
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	000	5	12/9/2023	NON-COMPETING CONTINUATION	$120,691
														Subtotal = $134,100

Issue Date FY: 2023 ( Subtotal = $134,100 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	001	4	1/27/2023	NON-COMPETING CONTINUATION	$13,409
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	000	4	12/17/2022	NON-COMPETING CONTINUATION	$120,691
														Subtotal = $134,100

Issue Date FY: 2022 ( Subtotal = $134,100 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	000	3	12/10/2021	NON-COMPETING CONTINUATION	$120,691
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Minority Health and Health Disparities Research	001	3	4/13/2022	NON-COMPETING CONTINUATION	$13,409
														Subtotal = $134,100

Issue Date FY: 2021 ( Subtotal = $134,100 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Minority Health and Health Disparities Research	000	2	12/16/2020	NON-COMPETING CONTINUATION	$120,691
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Minority Health and Health Disparities Research	001	2	3/16/2021	NON-COMPETING CONTINUATION	$13,409
														Subtotal = $134,100

Issue Date FY: 2020 ( Subtotal = $134,100 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Minority Health and Health Disparities Research	000	1	4/16/2020	NEW	$134,100
														Subtotal = $134,100

Grand Total All Awards = $670,500

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The SMART-CV Study: Systems Modeling Approaches to Reducing Disparities in Cardiovascular Diseases

Award Number: K01MD014163

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/16/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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