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Maternal History of Childhood Maltreatment and Perinatal Cardiometabolic Health

Award Number: K01HD120749
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Maternal History of Childhood Maltreatment and Perinatal Cardiometabolic Health - Maternal cardiometabolic disorders of pregnancy, including gestational diabetes, eclampsia, and pre- eclampsia, are a leading cause of maternal death and increase health risk for mothers long after birth. Maternal history of child maltreatment exposure, i.e., physical abuse, sexual abuse, emotional maltreatment, or neglect occurring prior to age 18, is a robust risk factor for physical and mental health problems and cardiometabolic disorders of pregnancy. Childhood maltreatment negatively impacts mental health and can become “biologically embedded.” This embedding alters brain structure and function and can change immune and cardiovascular system functioning. These biological changes may subsequently affect the body's responses to the physiological demands of pregnancy and postpartum cardiometabolic re-regulation. Due to a lack of longitudinal studies, effects of biological embedding during the perinatal period have not been rigorously tested. This application leverages two longitudinal cohort studies with complementary designs to address this gap and advance knowledge about the impact of trauma history on perinatal health. Samples include: (1) Pregnancy Cohort with detailed biological and psychological data collected at 6 timepoints from pregnancy through 24 months postpartum, and (2) Child Maltreatment Cohort 30-year follow up, including individuals with and without child protective services records who completed assessments of physical and mental health in childhood and adulthood, with pregnancy diagnoses abstracted from medical records. These two samples are uniquely suited to address the following aims: Aim 1: Test the impact of child maltreatment on cardiometabolic processes pre-pregnancy, in pregnancy, and through 24mo postpartum; Aim 2: Test pre-pregnancy and in- pregnancy maltreatment-related biological changes in neuroendocrine and immune functioning as mediators linking child maltreatment on cardiometabolic-related pregnancy outcomes; and Aim 3: Evaluate the impact of maternal pre-pregnancy and in-pregnancy psychological functioning as an alternate pathway linking child maltreatment exposure and cardiometabolic-related pregnancy outcomes. Use of longitudinal assessments before, during, and through 24 months postpartum is innovative and will advance our knowledge of the intermediate processes underlying the negative impact of childhood maltreatment on women’s health. Few researchers are currently dedicated to bridging child maltreatment science and perinatal health, which is a challenge to scientific progress. This research training program will provide the PI, a clinical psychologist and child maltreatment researcher, with multidisciplinary training and mentorship from field-leading experts in perinatal health and pregnancy physiology, biological embedding of child maltreatment in multiple body systems, and integration of physical and mental health. The PI will gain the necessary training and skills needed to accomplish research aims and launch an independent research program dedicated to trauma- informed perinatal research ultimately aimed at reducing the burden of chronic disease among women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $130,072 )
2026	2026	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Child Health and Human Development Extramural Research	000	1	9/17/2026	NEW	$130,072
														Subtotal = $130,072

Grand Total All Awards = $130,072

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Maternal History of Childhood Maltreatment and Perinatal Cardiometabolic Health

Award Number: K01HD120749

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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