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Exposure to Per- and Polyfluoroalkyl Substances and Prostate Cancer: Opportunities for Prevention and Early Detection

Award Number: K01ES035734
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Exposure to Per- and Polyfluoroalkyl Substances and Prostate Cancer: Opportunities for Prevention and Early Detection - PROJECT SUMMARY Prostate cancer (CaP) is the leading non-cutaneous cancer in men, accounting for roughly 1 in 5 new cases and 1 in 10 deaths from cancer per year. Few modifiable risk factors have been identified for CaP, limiting opportunities for primary prevention. In the US, Black men experience over twice the rate of mortality from CaP compared to White men, disparities that are partly explained by differences in neighborhood environmental context. Black men are often exposed to higher burden of environmental pollutants due to segregation and neighborhood disinvestment, which may contribute to disparities. Per- and polyfluoroalkyl substances (PFAS) are synthetic industrial chemicals of public health concern due to their ubiquitous presence and persistence in the body and environment, as well as growing evidence of their adverse health impacts. Certain PFAS have been classified as Group 2B (“possible”) carcinogens by the Institute of Agency for Cancer. Some studies in populations with high occupational or community exposures to PFAS have shown elevated risk of CaP, but few studies have examined these associations in large racially-diverse, population-based studies. I propose to study three commonly measured PFAS (PFOA, perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA) as potential risk factors for aggressive CaP and CaP disparities in New Jersey. I will develop a spatiotemporal model of drinking water PFAS exposure using multiple geographic datasets capturing business, hydrology, meteorologic, and census variables. Modeled PFAS exposure will be linked to masked residential address histories collected from men diagnosed with CaP in the New Jersey State Cancer Registry to estimate the risk of advanced CaP associated with increasing levels of PFAS. I will then conduct a pilot study among patients seeking CaP treatment at the Rutgers Cancer Institute of New Jersey. I will evaluate differences in PFAS souces by different sociodemographic groups, and study associations between serum PFAS and risk of biochemical reccurrence among men treated for CaP. This research will be complemented by a training program to develop knowledge and skills in health effects of endocrine-disrupting chemicals, spatiotemporal modeling of environmental chemicals, primary data collection and biospecimen collection, and molecular alterations involved in prostate carcinogenesis. I have invited a multidisciplinary team of environmental and cancer researchers to support my training. My short-term goals are to develop expertise in pathways through which PFAS and related endocrine-disrupting chemicals influence CaP, and disseminate findings through conference presentations and publications. My long-term goal is to become an independent scientist and expert in multilevel environmental and biological pathways that influence CaP progression and outcomes. Preliminary data generated through this project will support the development of an R01 proposal to clarify mechanisms through which PFAS and other endocrine-disrupting chemicals influence tumor biology and risk of recurrence following treatment for CaP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $184,962 )
2026	2026	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Environmental Health	000	3	2/2/2026	NON-COMPETING CONTINUATION	$184,962
														Subtotal = $184,962

Issue Date FY: 2025 ( Subtotal = $184,921 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Environmental Health	000	2	3/19/2025	NON-COMPETING CONTINUATION	$184,921
														Subtotal = $184,921

Issue Date FY: 2024 ( Subtotal = $184,912 )
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Environmental Health	000	1	2/28/2024	NEW	$184,912
														Subtotal = $184,912

Grand Total All Awards = $554,795

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Exposure to Per- and Polyfluoroalkyl Substances and Prostate Cancer: Opportunities for Prevention and Early Detection

Award Number: K01ES035734

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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