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NEW BIOMARKERS OF NEUROTOXICITY

Award Number: K01ES012653
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/09/2004
PERIOD OF PERFORMANCE END DATE: 02/28/2009

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NEW BIOMARKERS OF NEUROTOXICITY - DESCRIPTION (provided by applicant) This proposal will allow the Principal Investigator (PI) to gain knowledge and skills in Environmental Epidemiology under the direct supervision of a highly qualified sponsor, which will build on and extend his previous expertise in neurobiology, further enhancing his potential to develop into an independent investigator. The PI is trained in cellular and molecular aspects of neurobiology, and has had some exposure to epidemiology, including some classes at the Harvard School of Public Health taken on a part-time basis. During the first 3 years of this proposal, course work is proposed to attain needed skills in statistical methods for environmental epidemiology, molecular and genetic epidemiology, and neuroepidemiology. This course work, combined with the research to be conducted during this proposal will enable the principal investigator to obtain a doctorate in environmental epidemiology from the Harvard School of Public Health, thus enabling him to be a very competitive candidate for a tenure-track faculty position, which is the long-term goal of the candidate. The environment at the Harvard School of Public Health is an excellent one to accomplish the candidate's goals. The mentor is a recognized leader in the field of environmental epidemiology who has mentored other K-awardees. The school has a vibrant community of epidemiologists of all types, including genetic and neuro-epidemiologists with whom the candidate can interact. On-going seminar series in, among other topics, statistical methods and chronic (including neurologic) disease, provide fertile ground for learning, intellectual interactions, and development of ideas. The overall scientific goal of this study is to explore the use of novel biomarkers of neurotoxicity. In particular, the candidate proposes to build on his past neurobiology research to examine the effects of lead exposure on psychophysiologic measures of learning in the context of fear and anxiety, as well as the effects of lead on fine motor control as manifested through a new device for sophisticated analyses of handwriting and on autonomic nervous system control of cardiac function. This proposal focuses on lead not only because of the important public health consequences of lead exposure, but also because the extensive research experience with aspects of low-level lead exposure provides a solid foundation from which to explore these relatively new biomarkers of neurotoxicity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $128,802 )
2008	2008	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Environmental Health	000	5	4/8/2008	NON-COMPETING CONTINUATION	$128,802
														Subtotal = $128,802

Issue Date FY: 2007 ( Subtotal = $125,052 )
2007	2007	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Environmental Health	000	4	3/2/2007	NON-COMPETING CONTINUATION	$125,052
														Subtotal = $125,052

Issue Date FY: 2006 ( Subtotal = $121,689 )
2006	2006	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Environmental Health	000	3	2/24/2006	NON-COMPETING CONTINUATION	$121,689
														Subtotal = $121,689

Issue Date FY: 2005 ( Subtotal = $121,378 )
2005	2005	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	2	2/26/2005	NON-COMPETING CONTINUATION	$121,378
														Subtotal = $121,378

Issue Date FY: 2004 ( Subtotal = $116,386 )
2004	2004	HARVARD UNIVERSITY MEDICAL SCHOOL	643 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Environmental Health	000	1	4/9/2004	NEW	$116,386
														Subtotal = $116,386

Grand Total All Awards = $613,307

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NEW BIOMARKERS OF NEUROTOXICITY

Award Number: K01ES012653

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/09/2004

PERIOD OF PERFORMANCE END DATE: 02/28/2009

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