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Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokers

Award Number: K01DA047433
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/15/2019
PERIOD OF PERFORMANCE END DATE: 12/31/2023

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Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokers - Abstract The prevalence of e-cigarette use has increased dramatically in recent years, particularly among young adults. Because e-cigarettes deliver fewer toxicants than combustible cigarettes, they likely offer improved health outcomes for current smokers who switch completely. However, many smokers who try using e-cigarettes do not switch completely, abandoning e-cigarettes altogether or continuing to use both products. Thus, it is important to understand the factors that lead to these variable tobacco use patterns. One of the primary determinants of e-cigarette uptake and changes in smoking behavior is the reinforcement value delivered by e- cigarette products. Product characteristics that impact nicotine delivery and sensorimotor characteristics are most likely to impact relative reinforcement value. Two of the primary product-level determinants of nicotine delivery and sensorimotor characteristics are the nicotine concentration of e-liquid and the power of the e- cigarette device. The proposed research project will investigate the impact of these characteristics on relative reinforcement value and tobacco use patterns. Current smokers (n=180) will receive an e-cigarette and e-liquid to take home and use over a three-week period. In a double-blind 2x2 design, participants will be randomly assigned to receive a low (3 mg) or high (12 mg) nicotine concentration, and either a low (20 W) or high (50 W) e-cigarette power setting. Participants will return to the lab each week to complete laboratory assessments of relative reinforcement value and provide breath and urine samples for biomarker assessments of smoke and nicotine exposure. Participants will also complete daily electronic diaries assessing tobacco use. Thus, the proposed design includes both lab-based and ecological assessments of reinforcement and tobacco use. Equal numbers of young adult (18-25) and older adult (>25) participants will be recruited to allow for exploratory analyses on the impact of age. The K01 candidate, Dr. Tracy Smith, aims to develop an independent research portfolio that seeks to understand how 1) contextual, individual, and product characteristics contribute to the use of tobacco products, and 2) we can leverage this information to improve public health through tobacco regulation, policy, and public health interventions. The proposed research project described here, along with clear training objectives, will provide the skills necessary to achieve that goal. Training objectives include gaining expertise in non-cigarette tobacco products, tobacco control research, developmental differences in tobacco use, applied research methodologies, and grant-writing. A strong team of mentors have been assembled with expertise in each of these areas. MUSC provides a stellar training environment to allow K-awardees to transition to independent research funding. The training described here is a clear progression from Dr. Smith’s prior work, provides necessary skills for obtaining research independence, and will launch Dr. Smith’s research independence in substantial, measurable ways.!


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$38,695 )
2024	2023	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	5	5/6/2024	NON-COMPETING CONTINUATION	-$38,695
														Subtotal = -$38,695

Issue Date FY: 2023 ( Subtotal = $186,872 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	5	11/22/2022	NON-COMPETING CONTINUATION	$186,872
														Subtotal = $186,872

Issue Date FY: 2022 ( Subtotal = $186,872 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	4	11/26/2021	NON-COMPETING CONTINUATION	$186,872
														Subtotal = $186,872

Issue Date FY: 2021 ( Subtotal = $186,872 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	3	12/4/2020	NON-COMPETING CONTINUATION	$186,872
														Subtotal = $186,872

Issue Date FY: 2020 ( Subtotal = $240,872 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	2	12/19/2019	NON-COMPETING CONTINUATION	$186,872
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	001	2	5/6/2020	SUPPLEMENT FOR EXPANSION	$54,000
														Subtotal = $240,872

Issue Date FY: 2019 ( Subtotal = $186,872 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Drug Use and Addiction Research Programs	000	1	1/10/2019	NEW	$186,872
														Subtotal = $186,872

Grand Total All Awards = $949,665

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Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokers

Award Number: K01DA047433

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/15/2019

PERIOD OF PERFORMANCE END DATE: 12/31/2023

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