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Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias

Award Number: K01AG057836
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias - PROJECT SUMMARY/ABSTRACT This K01 Career Development Award will support the training and career development of a junior investigator, Dr. Sarinnapha Vasunilashorn, in patient-oriented aging research. The overall goal of the proposal is to provide Dr. Vasunilashorn with critical skills and development of experience and competence as an independent, translational researcher in delirium and Alzheimer's Disease and Related Dementias (ADRD). Specific training goals include: 1) obtaining experience in primary data collection within a clinical setting, 2) expansion of her analytic skillset in advanced longitudinal methods and genetic data analysis, and 3) building an in-depth knowledge base of ADRD. These training goals will be conducted in coordination with a set of specific research projects based on Dr. Vasunilashorn's preliminary data that reports on the association between plasma inflammatory markers and the incidence and severity of postoperative delirium in older patients without ADRD undergoing non-cardiac surgery. Delirium and ADRD have strong epidemiological associations: ADRD has long-been recognized as a risk factor for delirium, and recently delirium has been implicated as a risk factor for incident ADRD. Although this points to a clear link between delirium and ADRD, the shared pathophysiology underlying these relationships remains largely unknown. In the proposed K01 Specific Aims, Dr. Vasunilashorn will address this gap in knowledge and substantially extend her preliminary studies that have focused only on plasma-based markers of inflammation by examining whether both plasma and cerebrospinal fluid (CSF)-based measures of neuroinflammation and neuronal injury are associated with postoperative delirium, long-term cognitive decline, and incident ADRD, and evaluate whether genetic risk modifies these associations. These studies will leverage the considerable resources of: 1) the NIA-funded program project, the Successful Aging after Elective Surgery Study (SAGES; P01AG031720), and 2) the Healthier Postoperative Recovery Study (HiPOR; R21AG048600). This proposal is highly novel in examining markers of neuroinflamamtion and neuronal injury that will advance our understanding of the pathophysiologic mechanisms underlying the delirium-ADRD relationship, a largely underexplored area that represents a top priority area of the NIH (PAR-17-038). Importantly, the results will inform pathophysiologically targeted treatment for inflammation to provide neuroprotection and identify important variables to refine delirium risk prediction strategies thereby potentially preventing delirium and reducing ADRD. Ultimately, this work will pave the way and provide the foundation for the launch of Dr. Vasunilashorn's independent research career that will explore the pathophysiologic linkages of delirium and ADRD, two major threats to the independence and quality of life of all older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$259 )
2024	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	5	8/7/2024	NON-COMPETING CONTINUATION	-$259
														Subtotal = -$259

Issue Date FY: 2022 ( Subtotal = $116,886 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	5	3/21/2022	NON-COMPETING CONTINUATION	$116,886
														Subtotal = $116,886

Issue Date FY: 2021 ( Subtotal = $115,018 )
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	4	3/17/2021	NON-COMPETING CONTINUATION	$115,018
														Subtotal = $115,018

Issue Date FY: 2020 ( Subtotal = $113,187 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	3	3/12/2020	NON-COMPETING CONTINUATION	$113,187
														Subtotal = $113,187

Issue Date FY: 2019 ( Subtotal = $110,633 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	2	3/28/2019	NON-COMPETING CONTINUATION	$110,633
														Subtotal = $110,633

Issue Date FY: 2018 ( Subtotal = $109,378 )
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Aging Research	000	1	7/3/2018	NEW	$109,378
														Subtotal = $109,378

Grand Total All Awards = $564,843

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Shared Pathophysiology of Postoperative Delirium and Alzheimer's Disease and Related Dementias

Award Number: K01AG057836

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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