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What Mechanisms Underlie Top-Down Modulation of Human Visual Cortex?

Award Number: K00EY036804
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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What Mechanisms Underlie Top-Down Modulation of Human Visual Cortex? - PROJECT SUMMARY/ABSTRACT The human brain is adept at constructing coherent perceptual experiences, despite an environment overflowing with more information than can be processed at any given moment. Out of necessity, top-down cognitive processes, such as attention and working memory, play a key role in regulating what we can and cannot perceive. What neural computations drive this regulation of perception? While computational models have been proposed to account for the effects of attention and working memory on visual processing, there is a lack of empirical evidence testing these models in humans. This project will bridge this gap by pairing computational modeling with non-invasive neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), to study the brain mechanisms underlying attention, perception, and working memory. By using these techniques to track the neural fate of visual information across human visual cortex during selective attention tasks, we will reveal the specific mechanisms by which top-down processes improve our ability to see. In the long-term, development of a computational model will better quantify the top- down regulation of visual processing – information key to vision scientists and basic researchers investigating impaired cognition in patient populations. The aims of this project align with the mission of the NINDS and the BRAIN Initiative, building innovative multi-modal neuroimaging approaches to understand the brain mechanisms that underlie attention, perception, and working memory, with potential for guiding the diagnoses and treatment of related disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $84,862 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Vision Research	000	5	8/24/2026	NON-COMPETING CONTINUATION	$84,862
														Subtotal = $84,862

Issue Date FY: 2025 ( Subtotal = $84,862 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Vision Research	000	4	8/20/2025	NON-COMPETING CONTINUATION	$84,862
														Subtotal = $84,862

Issue Date FY: 2024 ( Subtotal = $84,862 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Vision Research	000	3	7/3/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$84,862
														Subtotal = $84,862

Grand Total All Awards = $254,586

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What Mechanisms Underlie Top-Down Modulation of Human Visual Cortex?

Award Number: K00EY036804

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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