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Neural Mechanisms for memory-guided visual behavior in humans

Award Number: K00EY031607
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/28/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Neural Mechanisms for memory-guided visual behavior in humans - Project Summary Memory allows us to use previous experience to guide current behavior. Computational models of episodic memory propose that recalling an event from the past involves reinstating patterns of cortical activity that were evoked when the event occurred. While there is considerable evidence for reinstatement within early sensory areas, recent evidence suggests that reinstatement also occurs in higher-level regions, such as lateral parietal cortex, that are strongly predictive of memory success. However, the significance of reinstatement in lateral parietal cortex and its relation to reinstatement in sensory areas is not well understood. Understanding how areas like lateral parietal cortex represent, transform, and prioritize information from sensory areas will be critical to building a full model of how distributed brain networks support healthy and dysfunctional memory. Addressing these gaps in understanding will require a multidisciplinary approach that relies on innovative fMRI analyses, computational modeling, and integrating evidence from neuroimaging and electrophysiology. My dissertation work so far has used fMRI approaches to test the hypothesis that lateral parietal cortex represents sensory content during memory retrieval. This work has produced several significant results in favor of this hypothesis and has involved the development of new fMRI methods. In the proposed research and training program, I will use computational models of visual encoding to discriminate between competing hypotheses of how topographic maps in parietal cortex encode spatial information during memory retrieval. This experience will provide training in visual neuroscience and computational modeling, allowing me to develop expertise with diverse approaches to studying episodic memory. In the proposed postdoctoral training phase, I will gain theoretical and methodological training in electrophysiological measurements collected from humans. The combination of fMRI and electrophysiology measurements will allow me to test novel hypotheses about how memory signals propagate through time across distinct brain regions, and to generate findings that unify research performed in human and non-human animal systems. This research program has significant potential to generate novel understanding of the cortical mechanisms that support memory retrieval, to bridge findings across measurements techniques, and to inform the treatment of aging- and disease-related memory disorders. I am confident that the training provided by this research program will allow me to develop the diverse theoretical and methodological expertise needed to conduct independent research on a core set of questions in systems and cognitive neuroscience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	11/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $84,624 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	1/31/2023	NON-COMPETING CONTINUATION	$84,624
														Subtotal = $84,624

Issue Date FY: 2022 ( Subtotal = $84,624 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/28/2022	NON-COMPETING CONTINUATION	$84,624
														Subtotal = $84,624

Issue Date FY: 2021 ( Subtotal = $84,624 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/10/2021	NON-COMPETING CONTINUATION	$82,188
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	4/7/2021	NON-COMPETING CONTINUATION	$2,436
														Subtotal = $84,624

Issue Date FY: 2020 ( Subtotal = $82,188 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/13/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	6/5/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$82,188
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	5/1/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$73,548
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/12/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$73,548
														Subtotal = $82,188

Grand Total All Awards = $336,060

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Neural Mechanisms for memory-guided visual behavior in humans

Award Number: K00EY031607

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/28/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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