The State of Indiana seeks to apply for State Opioid Response grant funding to address the substance use crises affecting so many Hoosiers statewide. Since the first day of Governor Eric Holcomb’s administration in 2017, he has called for an “all hands on deck” approach to the growing drug crisis in Indiana. The Holcomb administration has made addressing the drug crisis one of the pillars of his Next Level Agenda. The population of focus for the State Opioid Response 3 (SOR 3) grant includes individuals across the lifespan who are 1) At risk for developing Opioid Use Disorder (OUD) or Stimulant Use Disorder (StUD), 2) At risk of overdose injury or death due to opioid or stimulant use, and 3) In need of treatment and recovery resources for OUD and StUD. GPRA data for the SOR 1 and SOR 2 grants also counts 1,591 individuals with an Opioid-related Diagnosis and 1,319 with a Stimulant or Cocaine Use Disorder. Based on information gathered for the Needs Assessment, using the SAMHSA’s National Survey on Drug Use & Health (NSDUH), 12.88%, a total of 709,681, of Indiana’s population over the age of 12 are estimated to have used an illicit substance in the month prior to the survey. In 2020, the same survey estimates 13.82%, a total of 761,475, of the surveyed population have some type of substance use disorder. According to the Indiana Department of Health (IDOH), from 2020 to 2021, there were 4,249 recorded overdose deaths in the State of Indiana. During the same timeframe, 37,962 naloxone events were reported across the State by first responders, as reported by the Indiana Department of Homeland Security. In 2021, according to IDOH, there were 6,112 reported emergency department visits due to any opioid and 14,424 visits due to any drug. During the State Opioid Response 3 grant period, Indiana plans to address the ongoing opioid and stimulant crisis by 1) Increasing access to evidence based treatment and recovery resources to all people in Indiana with OUD or StUD; 2) Decreasing the total number of drug overdose deaths in State by 10%; and 3) Increasing the number of addiction professionals within the State providing treatment and recovery services for people with OUD and StUD.