The overarching goal of the Arizona State Opioid Response project is to increase access to MAT treatment, coordinated and integrated care, OUD/stimulant use disorder recovery support services and prevention activities to reduce the prevalence of OUDs, stimulant use disorder and opioid-related overdose deaths. The project approach includes developing and supporting state, regional, and local level collaborations and service enhancements to develop and implement best practices to comprehensively address the full continuum of care related to opioid misuse, abuse and dependency. The proposed activities within the Arizona Opioid State Opioid Response project will work synergistically with existing efforts to reduce stimulant use disorder, OUDs and opioid-related deaths by: (1) sustaining and enhancing naloxone distribution; (2) increasing localized community prevention efforts; (3) expanding navigation and access to MAT through 24/7 OTPs, Medication Units and extended hours OTPs; and (5) expanding access to recovery support services including housing, peer supports and supportive recovery programming. Measureable objectives to reduce stimulant use disorder, OUDs and opioid-related deaths will include: number of naloxone kits disseminated; MAT utilization and retention; use of the CSPMP; rates of opioid prescribing; rates of individuals in prescribed doses in excess of 50 MEDDs; community knowledge and prevention behavior; ED utilization; and rates of fatal and non-fatal overdose. Target population will, at minimum, serve: individuals re-entering the community from correctional settings; individuals in rural and isolated areas; individuals experiencing homelessness; tribal populations; veterans, military service members and military families; pregnant women and parents with OUD; individuals with physical disabilities and individuals who have experienced trauma, toxic stress or adverse childhood experiences (ACEs). The project will serve 250,000 unduplicated individuals between year one and year two under prevention activities and serve 7,908 unduplicated individuals with treatment and recovery services in year one and an additional 11,863 unduplicated individuals in year two, for a total project reach of 19,771 unduplicated individuals.