The Native American Health Center, Inc. (NAHC) proposes the implementation of Red Vision at its clinic sites located in the San Antonio/ Fruitvale neighborhoods of Oakland, California and the Mission Neighborhood of San Francisco, California. The target population includes Urban American Indian/ Alaska Native (AIAN) and other underserved youth aged 12+ and their families that reside in and around NAHC’s clinic neighborhoods. The primary geographic catchment area where the project will be implemented are zip codes 94601 representing East Oakland in Alameda County and 94110 representing the Inner Mission of San Francisco in San Francisco County. However, due to proximity and the availability of AIAN culturally specific programming, NAHC’s member profile also includes individuals that reside in neighboring zip codes and urban AIAN individuals that reside in NAHC’s 5-county radius including Alameda, San Francisco, Contra Costa, Marin, San Mateo, and Santa Clara Counties. Red Vision will serve 100 youth and their families annually and provide outreach and engagement to an additional 500 community members annually. The goals of the Red Vision project are as follows: Goal 1. Build community-driven capacity efforts to reduce the risk factors that may contribute to the onset and progression of substance misuse and its related problems for AIAN and other underserved youth aged 12+ and their families that reside in and around NAHC’s clinic neighborhoods. Goal 2. Decrease the onset and progression of substance misuse and its related problems by implementing accessible, culturally-responsive, evidence and community based, best practices for AIAN and other underserved youth aged 12+ and their families that reside in and around NAHC’s clinic neighborhoods.