Summary: Substance Misuse Awareness and Sexual Health (SMASH) will utilize a navigation approach to provide comprehensive and culturally appropriate services for 350 racial/ethnic minority men in Bexar County, Texas who are at risk for substance misuse, HIV/AIDS, and Hepatitis. Centralized in University Health’s outpatient primary care clinic, SMASH will implement an array of evidence-based prevention services (e.g. SBIRT, WHAM) to effectively address the needs of at-risk racial/ethnicity men. Population: SMASH will serve 350 (50 Y1, 75 Y2, 75 Y3, 75 Y4, 75 Y5) predominately Hispanic and Black minority men, ages 18 years and older, especially males at risk for HIV/AIDS, males who have sex with other males (MSM), and individuals with unstable housing, and reside in Bexar County, Texas. Clients will be recruited from University Health’s outpatient clinic as well as through community partners. Interventions: SMASH prevention services will be implemented by a Prevention Navigator who will provide outreach, navigation, HIV/VH testing, evidence-based prevention education, and referrals for housing support services. Social media strategies, including awareness campaigns, and community outreach will be implemented to recruit, engage, facilitate behavior change, and reduce stigma. Goals and Objectives: Guided by the Strategic Prevention Framework (SPF) process, the purpose of SMASH is to prevent substance misuse and the transmission of HIV and hepatitis among the high risk population of focus. To accomplish this goal, SMASH will implement three primary objectives: 1) Provide culturally, gender, and age-appropriate evidenced-based HIV, VH and substance misuse prevention interventions to a minimum of 350 minority males including MSMs (ages 18+) in Bexar County over 5 years; 2) Implement social media/outreach strategy to create an impactful awareness campaign that facilitates positive behavior change (healthier decisions), increased uptake of testing, condom use, etc. and reduces stigma among the population of focus; 3) Collaborate with local community organizations to provide a continuum of care services to meet the needs of the population of focus.