The HIV Education, Awareness, Referral and Treatment for Substance Use Disorders (HEARTS) at Open Gate Program will provide integrated substance use disorders (SUD) education and prevention services, HIV and viral hepatitis prevention education, HIV and Hepatitis C testing, and navigation services to racial/ethnic minority adults. This program will have a targeted focus on young adults ages 18-30 who are experiencing homelessness, identify as LGBTQ, and are at risk for SUD and HIV. The program is a collaborative effort among the Center for Neurobehavioral Research on Addiction at the University of Texas Health Science Center at Houston (UTHealth), Tony's Place, and the Open Gate Mission. This program seeks to expand upon the currently funded TCE-HIV: High Risk Populations program (UT-HEARTS) which currently provides HIV testing and SUD treatment to racial/ethnic minority men and women at high risk for HIV who have a diagnosed SUD or co-occurring psychiatric disorder (COD). HEARTS at Open Gate will provide culturally consistent, inclusive and trauma-informed HIV/STD and substance abuse screening, brief intervention and referral to treatment as part of a Prevention Navigator Program. Prevention programming will include HIV/Hepatitis C counseling and testing, evidence-based prevention practices including Motivational Interviewing, the Real Men are Safe (REMAS) intervention, and the Safer Sex Skills Building intervention for women. Peer support specialists will serve as prevention navigators providing case management by leveraging our extensive network of collaborative partnerships to link participants to mental health treatment, substance use disorders treatment, housing support services, confirmatory HIV testing, primary medical care, and HIV medical care. These peer support specialists will provide follow-up to ensure engagement and retention in care. The overarching goal of this program will be to reduce substance abuse, reduce risky sexual behaviors, and prevent new cases of HIV and Hepatitis within this population. Activities in the program will be aligned with SAMHSA's overall purpose of increasing engagement in prevention activities, providing training and education about the risks associated with substance misuse, providing education about HIV/AIDS, and providing linkages to services for individuals with HIV or at risk for HIV. The objectives of the program are to: (1) Form a community advisory board involving young adults in the design and implementation of prevention and education strategies; (2) Increase access to substance use disorders screening, prevention and treatment services; (3) Increase the number of ethnic minority young adults who are aware of their HIV status; (4) Increase knowledge about the cause, transmission, progression and prevention of HIV/HCV and other STDs; (5) Increase access to HIV and substance use disorders prevention services; and (6) Using a peer navigator approach, provide linkages to care for HIV and substance use disorders and ensure engagement and retention in care.