Enhancing STI Awareness and Prevention among the Oglala Sioux Tribe - The Oglala Sioux Tribe on the Pine Ridge Reservation faces a significant rise in sexually transmitted infections (STIs), with gonorrhea cases increasing by 18% and syphilis cases by 900% in 2022. This grant proposal seeks funding to launch a comprehensive STI awareness and prevention program. The initiative will focus on education, testing, treatment access, and promoting healthy relationships within the Pine Ridge Reservation to reduce STI rates and promote sexual health through culturally sensitive and sustainable initiatives, including school-based Healthy Relationship Training and a community-wide Public Awareness Campaign. The alarming increase in STI cases on the Pine Ridge Reservation reflects heightened transmission and improved testing and reporting. Gonorrhea cases rose from 181 to 213, and syphilis cases surged from 4 to 40, affecting counties such as Minnehaha, Pennington, Todd, Oglala Lakota, and Dewey. The Oglala Sioux Tribe faces health disparities, limited healthcare access, socioeconomic challenges, and cultural barriers, underscoring the need for a targeted response to improve sexual health outcomes and overall well-being. Our program will increase STI awareness and education through culturally relevant materials, workshops, and seminars across the nine districts of the Pine Ridge Reservation. Implementing Healthy Relationship Training in schools will educate students on STI prevention, while local media and social platforms will promote awareness. Promoting STI testing and treatment is another critical objective, aiming to increase testing rates and ensure those who test positive receive appropriate care. Collaborations with healthcare providers will streamline testing and treatment processes. Prevention efforts will be enhanced by distributing condoms and promoting monogamous relationships, reducing sexual partners, and promoting abstinence through culturally sensitive messaging. The Oglala Sioux Tribe’s health programs have provided comprehensive health services on the Pine Ridge Reservation for over two decades. Our robust administrative infrastructure and experienced staff support these programs, ensuring efficient operation and effective service delivery. To evaluate the success of this project, we will measure the reach of educational efforts, increased STI testing rates, and the reduction in STI cases. Participant feedback, data from health centers, and insights from community advisory boards will guide program adjustments. Ensuring the long-term impact involves continuing partnerships with health centers and community leaders, seeking additional funding, and training community health workers to sustain educational and testing efforts. Establishing a community advisory board and a peer education program will support ongoing guidance and engagement. Tribal leaders, elders, schools, youth organizations, and other community groups will be involved in planning and implementation. Existing community events will promote STI awareness and testing, encouraging community ownership through participatory approaches. In conclusion, this project addresses a critical health need for the Oglala Sioux Tribe by increasing STI awareness, promoting testing, and enhancing prevention efforts. By leveraging community strengths and fostering collaboration, we aim to reduce STI rates and improve the sexual health of our community. With the support of this grant, we can make a significant impact on the well-being of the Oglala Sioux Tribe now and in the future, ensuring the preservation of our rich cultural heritage and the continued strength of our community.