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Selective dissection of local and distributed neocortical inhibitory circuits underlying sensory representation

Award Number: F99NS129170
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Selective dissection of local and distributed neocortical inhibitory circuits underlying sensory representation - PROJECT SUMMARY/ABSTRACT The research proposed here is aimed at furthering our understanding of causal relationships between early neural circuit formation and adult behavior, and specifically how healthy brain development can go awry to result in deficits in sensory processing across a lifetime. Towards a deeper understanding of normal and aberrant neurodevelopmental processes, there is a critical need to deconstruct the driving pathophysiological mechanisms between developmental cortical hyperactivity and emergence of persistent maladaptive cognitive, sensory and social behaviors. Without such information, the promise of novel targets for early intervention in neurodevelopmental diseases will likely remain limited. During the F99 Phase, I will test if developmental hyperexcitation of pyramidal neurons leads to persistent adult hypersensitivity (Aim IA) and deficits in fast-spiking inhibitory neuron recruitment (Aim IB)—key neurophysiological and behavioral signatures seen in autism spectrum disorders and neurodevelopmental syndromes. In Aim II, I will complement my neurophysiological training in high density electrophysiological recordings and perform two-photon imaging of prefrontal cortex projections into sensory areas to test how they influence encoding and circuit dynamics regulated by local inhibitory neuron subtypes. This work will contribute to understanding the neurodevelopmental origins of hypersensitivity and will help to broaden our understanding of disturbances in spontaneous activity beyond genetic, immune and environmental factors by providing mechanistic insight into causal cell-type specific roles of pyramidal neuron and inhibitory neuron subtypes. The training for the F99/K00 Phases will complement my deep background in developing molecular technologies to dissect neocortical local and long-range projections driving complex behavior. In my own lab I will readily develop next-generation molecular technologies for dissecting neocortical computations across temporal and spatial scales with increasing biological complexity (genes, proteins, cells, circuits) underlying sensory processing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$4,244 )
2025	2023	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/24/2025	NON-COMPETING CONTINUATION	-$4,244
														Subtotal = -$4,244

Issue Date FY: 2023 ( Subtotal = $40,610 )
2023	2023	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/20/2023	NON-COMPETING CONTINUATION	$40,610
														Subtotal = $40,610

Issue Date FY: 2022 ( Subtotal = $39,509 )
2022	2022	CENTRAL MICHIGAN UNIVERSITY	119 BOVEE UNIVERSITY CTR	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/14/2022	NEW	$1,000
2022	2022	CENTRAL MICHIGAN UNIVERSITY (INC)	119 BOVEE UNIVERSITY CENTER	MOUNT PLEASANT	MI	48858	ISABELLA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/29/2022	NEW	$38,509
														Subtotal = $39,509

Grand Total All Awards = $75,875

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Selective dissection of local and distributed neocortical inhibitory circuits underlying sensory representation

Award Number: F99NS129170

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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