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The role of patterned spontaneous network activity in motor circuit activity

Award Number: F32NS105350
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2020

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The role of patterned spontaneous network activity in motor circuit activity - The nervous system uses neural circuits to generate cognition and behavior. These circuits are often disrupted in spinal cord injury or stroke, and are aberrant in mental disorders. One way to treat these conditions is to re- grow or modify neural circuits. Thus, understanding how neural circuits are assembled may aid in the design of regenerative therapies, and brain stimulation therapies to treat mental disorders. During circuit assembly, nervous systems exhibit patterned spontaneous network activity (PaSNA). PaSNA is necessary to build a functional circuit in vertebrates and invertebrates, yet we know surprisingly little about the mechanisms involved. My strategy is to use Drosophila embryonic and larval locomotion as a system to uncover the underlying molecular and cellular mechanisms by which PaSNA promotes neural circuit assembly. The advent of new tools in Drosophila, such as optogenetic reagents, Gal4 lines to manipulate single neurons in the central nervous system (CNS), and a transmission electron microscopy connectome of the entire CNS make this a powerful system for studying neural circuits. Similar to vertebrates, premotor neurons are required for PaSNA. This raises the questions that this proposal addresses: Which specific interneuron populations generate PaSNA, do different interneurons have different patterns of activity, and how does interneuron PaSNA drive motor circuit development? With the use of Gal4 lines unique to our system and genetically encoded calcium indicators, I will identify the interneurons participating in PaSNA. I will use a characterized circuit required for larval locomotion together with optogenetic tools to identify the effect of PaSNA in establishing circuit connectivity and function. This proposal will reveal (1) the neuronal components that generate PaSNA during locomotor circuit assembly, (2) whether PaSNA is stochastic or stereotypic with the population of active neurons, (3) whether there is a correlation between neuronal identity and participation in PaSNA; (4) whether PaSNA is required for locomotor circuit establishment, and (5) whether PaSNA is required for locomotor circuit function. These represent critical advances that will provide insight into the formation and function of neural circuits in both Drosophila and mammals, where PaSNA is a conserved element of neural circuit formation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/16/2023	NON-COMPETING CONTINUATION	$849
2023	2020	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/14/2023	NON-COMPETING CONTINUATION	-$849
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$849 )
2022	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	4	4/22/2022	NON-COMPETING CONTINUATION	-$848
2022	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/22/2022	NON-COMPETING CONTINUATION	$0
2022	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	4/22/2022	NEW	$0
2022	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/22/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = -$849

Issue Date FY: 2020 ( Subtotal = $10,458 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/19/2020	NON-COMPETING CONTINUATION	$0
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/2/2020	NON-COMPETING CONTINUATION	$10,458
														Subtotal = $10,458

Issue Date FY: 2019 ( Subtotal = $60,610 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/25/2019	NON-COMPETING CONTINUATION	$60,610
														Subtotal = $60,610

Issue Date FY: 2018 ( Subtotal = $58,654 )
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	9/12/2018	NEW	-$37,185
2018	2018	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	9/12/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$37,185
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	5/16/2018	NEW	$1,960
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/9/2018	NEW	$56,694
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	2/9/2018	NEW	$0
														Subtotal = $58,654

Grand Total All Awards = $128,873

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The role of patterned spontaneous network activity in motor circuit activity

Award Number: F32NS105350

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2020

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