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Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathing

Award Number: F32HL160102
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/18/2022
PERIOD OF PERFORMANCE END DATE: 02/17/2025

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Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathing - PROJECT SUMMARY Coordination of breathing with postinspiratory behaviors such as swallowing and laryngeal adduction is essential to health. Dysregulation of laryngeal activity during postinspiration and swallow occurs in many neurological and breathing-related disorders, such as obstructive sleep apnea, and can increase the risk of disordered swallow (dysphagia) and aspiration. Dysphagia is a major problem in patients with these diseases, and there are currently no treatments to cure or prevent dysphagia. This deficit is due in part to the lack of studies on coordination of breathing with laryngeal function of postinspiration and swallow. The recently described brainstem Postinspiratory Complex (PiCo) is thought to control postinspiration, yet its role in other laryngeal behaviors has not been studied. We test a fundamentally new hypothesis that excitatory medullary transmission from PiCo to the swallow pattern generator plays a role in swallow-related postinspiratory behavior. Our goals is to define the role of PiCo in postinspiratory laryngeal activity and swallow, and investigate potential coordination between the dorsal swallow group (DSG) and the ventral respiratory group (VRG). Based on preliminary data, we hypothesize that PiCo is a hub for both postinspiratory activity and swallowing, and has connections to the presumed swallow pattern generator in the nucleus tractus solitarius (nTS). We believe PiCo plays a role in swallow-related rhythmic activities which includes the nTS as the presumed swallow rhythm generator with projections to ventral respiratory centers. We use two in-vivo preparation: anesthetized and alert mouse combined with electrophysiology, novel optogenetics and Neuropixel recordings to test these hypotheses. We predict neural coordination of PiCo activity with respiratory and non-respiratory centers is similar between anesthetized and unanesthetized preparations. Investigating PiCo in an alert animal is important for characterizing the natural behaviors of swallow and laryngeal postinspiratory activity in a translational manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $78,892 )
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	National Center on Sleep Disorders Research	001	3	9/6/2024	NON-COMPETING CONTINUATION	$5,120
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	National Center on Sleep Disorders Research	000	3	12/27/2023	NON-COMPETING CONTINUATION	$73,772
														Subtotal = $78,892

Issue Date FY: 2023 ( Subtotal = $71,792 )
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	National Center on Sleep Disorders Research	000	2	2/15/2023	NON-COMPETING CONTINUATION	$71,792
														Subtotal = $71,792

Issue Date FY: 2021 ( Subtotal = $66,390 )
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	National Center on Sleep Disorders Research	001	1	8/10/2021	NEW	$0
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	National Center on Sleep Disorders Research	000	1	8/10/2021	NEW	$66,390
														Subtotal = $66,390

Grand Total All Awards = $217,074

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Characterizing the neural circuitry of postinspiratory behaviors and its coordination with breathing

Award Number: F32HL160102

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/18/2022

PERIOD OF PERFORMANCE END DATE: 02/17/2025

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