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REGULATORY ROLE OF IRON IN HEMATOPOIESIS

Award Number: F32HL086046
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/14/2007
PERIOD OF PERFORMANCE END DATE: 06/30/2009

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REGULATORY ROLE OF IRON IN HEMATOPOIESIS - DESCRIPTION (provided by applicant): Iron deficiency anemia is one of the most common forms of anemia and reduces the efficacy of erythropoietin therapy. Iron deficiency also is induced during the treatment of polycythemia vera because of the block in erythropoiesis induced during iron depletion. The negative effects of iron deficiency override both normal and enforced growth factor signaling. Preliminary data suggests that iron deficiency blocks erythroid differentiation at an early stage by increasing cell death and slowing cell division. To test this hypothesis, we propose two aims to further our understanding. First, we will use a physiologically relevant human peripheral blood stem cell model of iron deficiency to characterize erythroid differentiation, cell cycle effects and apoptosis. Second, we will determine what molecules affect erythropoiesis during iron deficiency. Key molecules known to be important in cell death and survival have been identified in preliminary experiments. The roles that these factors play will be determined by inhibition or add-back experiments using retroviral vectors. These experiments will provide insight into how iron regulates erythropoiesis and may provide novel targets for the treatment of anemia and thrombocytopenia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $58,036 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Blood Diseases and Resources Research	000	3	6/1/2008	NON-COMPETING CONTINUATION	$58,036
														Subtotal = $58,036

Issue Date FY: 2007 ( Subtotal = $55,852 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Blood Diseases and Resources Research	000	2	7/16/2007	NON-COMPETING CONTINUATION	$55,852
														Subtotal = $55,852

Issue Date FY: 2006 ( Subtotal = $54,342 )
2006	2006	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Blood Diseases and Resources Research	000	1	7/14/2006	NEW	$54,342
														Subtotal = $54,342

Grand Total All Awards = $168,230

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REGULATORY ROLE OF IRON IN HEMATOPOIESIS

Award Number: F32HL086046

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/14/2007

PERIOD OF PERFORMANCE END DATE: 06/30/2009

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