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Non-coding Genomic Determinants of Adipogenesis

Award Number: F32GM153131
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/20/2023
PERIOD OF PERFORMANCE END DATE: 12/19/2025

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Non-coding Genomic Determinants of Adipogenesis - Project Summary Cell identity is acquired by integrating multiple signaling inputs that establish complex gene regulatory networks over time. These signals are converted into expression profiles by the binding of transcription factors to non-coding regions of DNA known as enhancers. In human adipogenesis, multiple inputs converge onto a single gene, PPARG. PPARG responds to these inputs through two super-enhancers , which are dense collections of individual enhancers. The myriad of input signals that feed into adipogenesis and drive PPARG activation suggests the presence of complex regulatory logic within the two super-enhancers located up- and downstream of the PPARG coding region. For instance, Creb1 is an early input in adipogenesis that appears dispensable later, C/EBPb is required later and subsequently activates C/EBPa to maintain PPARG transcription, and finally PPARG itself autoregulates to drive PPARG output even further, as adipocytes adopt their terminal fate. The large genomic distances between enhancers and promoter, and the observation that chromatin remodeling is a key bottleneck in adipogenesis suggesta hierarchical model of PPARγ activation. We will systematically determine which functional units of the PPARG super-enhancers respond to diverse inputs by silencing individual super-enhancer modules in a temporally resolved manner during adipogenesis. We will combine these findings with direct observation and manipulation of chromatin contacts in single cells, in order to test whether efficient signal transduction from super-enhancers to promoter requires 2-way enhancer-promoter chromatin loops or complex multi-way contacts between super-enhancer modules and the promoter.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $74,284 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	2	12/5/2024	NON-COMPETING CONTINUATION	$74,284
														Subtotal = $74,284

Issue Date FY: 2024 ( Subtotal = $73,828 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	000	1	12/20/2023	NEW	$69,080
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	001	1	12/20/2023	NEW	$0
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Biomedical Research and Research Training	002	1	7/25/2024	NEW	$4,748
														Subtotal = $73,828

Grand Total All Awards = $148,112

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Non-coding Genomic Determinants of Adipogenesis

Award Number: F32GM153131

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/20/2023

PERIOD OF PERFORMANCE END DATE: 12/19/2025

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