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Imaging nanodomains and lipid rafts in membranes using iSCAT

Award Number: F32GM115236
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/16/2015
PERIOD OF PERFORMANCE END DATE: 11/15/2018

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Imaging nanodomains and lipid rafts in membranes using iSCAT - ¿ DESCRIPTION (provided by applicant): Growing biochemical evidence suggests that cell membranes segregate their components into nanoscopic platforms or 'rafts' to control signaling and trafficking across the membrane. Signaling is a key function of the cell, and it is unsurprising that raft formation has been proposed to influence a wide range of diseases, such as Alzheimer's, influenza, and diabetes. This project will shed further light on this issue by accomplishing 3 different aims. The development of a new microscopy technique capable of imaging membranes at nanometer scale and microsecond times- The limiting factor in current studies of lipid rafts is the limits of current imaging techniques. The characterization of model membranes at the nanoscale- Model membranes, composed of a just few components, will provide valuable information on the lipid interactions that drive the formation of lipid rafts Imaging live cells- Live cells will be imaged, and their nanoscale membrane structure correlated to the position of proteins known to associate with rafts. This will provide information on the actual behavior of cell membranes in organizing proteins. This project will answer questions about how cells are organized that will have immediate impact on the understanding of many diseases. This project will also develop tools that will enable many future experiments on how disease affects the functioning of a cell.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$9,624 )
2021	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE			GBR	Biomedical Research and Research Training	000	3	12/29/2020	NON-COMPETING CONTINUATION	-$9,624
														Subtotal = -$9,624

Issue Date FY: 2018 ( Subtotal = $9,850 )
2018	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Biomedical Research and Research Training	003	3	7/19/2018	NON-COMPETING CONTINUATION	$1,000
2018	2018	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Biomedical Research and Research Training	001	3	11/9/2017	NON-COMPETING CONTINUATION	$8,850
														Subtotal = $9,850

Issue Date FY: 2017 ( Subtotal = $8,850 )
2017	2017	UNIVERSITY OF OXFORD	UNIVERSITY OFFICES	OXFORD	OXFORDSHIRE	OX1 2JD		GBR	Biomedical Research and Research Training	001	2	4/7/2017	NON-COMPETING CONTINUATION	$8,850
														Subtotal = $8,850

Issue Date FY: 2015 ( Subtotal = $7,850 )
2015	2015	OXFORD UNIVERSITY, DEPT OF BIOCHEMISTRY & GENETICS LAB	UNIVERSITY OFFICES	OXFORD				GBR	Biomedical Research and Research Training	001	1	8/25/2015	NEW	$7,850
														Subtotal = $7,850

Grand Total All Awards = $16,926

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Imaging nanodomains and lipid rafts in membranes using iSCAT

Award Number: F32GM115236

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/16/2015

PERIOD OF PERFORMANCE END DATE: 11/15/2018

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