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VEGF-INDUCED ANGIOGENESIS AND SCAR FORMATION

Award Number: F32GM072196
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/20/2004
PERIOD OF PERFORMANCE END DATE: 08/19/2006

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VEGF-INDUCED ANGIOGENESIS AND SCAR FORMATION - DESCRIPTION (provided by applicant): During the first two trimesters of development, the fetus heals skin wounds in a scarless manner, a process that occurs very rapidly and without inflammation. In contrast, skin beyond the third trimester of development through adulthood heals more slowly, includes a significant inflammatory phase, and results in the formation of a permanent scar. Although adult wound repair exhibits a robust period of angiogenesis, wound angiogenesis has not been well described in scarless fetal healing. Our preliminary data suggests reduced levels of angiogenesis in scarless fetal wounds. The proposed studies will examine the contribution of wound angiogenesis to scar formation in fetal and adult skin. We will characterize wound angiogenesis and the production pattern of the pro-angiogenic molecule vascular endothelial growth factor (VEGF) and its receptors in fetal wound repair. In addition, we will examine the effects of VEGF-induced angiogenesis on scar formation using murine models of scarless fetal healing and adult wound repair. A better understanding of the scarless healing process that occurs in fetal skin could lead to the identification of therapeutic targets used to enhance the outcome of postnatal repair.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $49,928 )
2005	2005	LOYOLA UNIVERSITY MEDICAL CENTER							Biomedical Research and Research Training	000	2	7/18/2005	NON-COMPETING CONTINUATION	$49,928
														Subtotal = $49,928

Issue Date FY: 2004 ( Subtotal = $47,296 )
2004	2004	LOYOLA UNIVERSITY MEDICAL CENTER							Biomedical Research and Research Training	000	1	8/20/2004	NEW	$47,296
														Subtotal = $47,296

Grand Total All Awards = $97,224

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VEGF-INDUCED ANGIOGENESIS AND SCAR FORMATION

Award Number: F32GM072196

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/20/2004

PERIOD OF PERFORMANCE END DATE: 08/19/2006

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