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GENOMICS OF IMPROVED IMMUNITY IN DROSOPHILA MELANOGASTER

Award Number: F32GM068376
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2003
PERIOD OF PERFORMANCE END DATE: 07/31/2006

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GENOMICS OF IMPROVED IMMUNITY IN DROSOPHILA MELANOGASTER - DESCRIPTION (provided by applicant): Research in Drosophila melanogaster has made significant contributions to our understanding of both the mechanistic basis of immunity and the ecological and evolutionary factors contributing to phenotypic variation in immune system function. However, research into the molecular mechanisms of immunity has tended to neglect factors contributing to phenotypic variation in immune function, while research focused on the factors contributing to phenotypic variation has been compromised by an incomplete understanding of its genetic basis. Phenotypic changes may arise in responses to environmental changes (phenotypic plasticity) or due to changes in the genotype. The main goal of the proposed research is to examine changes in gene expression contributing to environmental and genetic improvements in the antimicrobial immune response in Drosophila melanogaster. The availability of the complete Drosophila genome, along with micro-chip gene arrays, allowing genome-wide analysis of gene expression, will provide an unprecedented examination of the genetic basis of improvements in immune function and the potential costs associated with these improvements. Results will contribute to understanding the mechanistic basis of insect immune function, the evolution of inducible defense, the maintenance of susceptibility to infectious disease, and to the link between the genotype and the phenotype.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $49,928 )
2005	2005	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	3	8/1/2005	NON-COMPETING CONTINUATION	$49,928
														Subtotal = $49,928

Issue Date FY: 2004 ( Subtotal = $47,296 )
2004	2004	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Biomedical Research and Research Training	000	2	7/9/2004	NON-COMPETING CONTINUATION	$47,296
														Subtotal = $47,296

Issue Date FY: 2003 ( Subtotal = $41,608 )
2003	2003	CORNELL UNIVERSITY, COLLEGE OF AGRICULTURE & LIFE SCI	**	ITHACA	NY	14850	TOMPKINS	USA	Genetics and Developmental Biology Research and Research Training	000	1		NEW	$41,608
														Subtotal = $41,608

Grand Total All Awards = $138,832

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GENOMICS OF IMPROVED IMMUNITY IN DROSOPHILA MELANOGASTER

Award Number: F32GM068376

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2003

PERIOD OF PERFORMANCE END DATE: 07/31/2006

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