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PHARMACOKINETICS OF DBP IN UTERO TO ASSESS HUMAN RISK

Award Number: F32ES013370
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2004
PERIOD OF PERFORMANCE END DATE: 06/30/2006

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PHARMACOKINETICS OF DBP IN UTERO TO ASSESS HUMAN RISK - DESCRIPTION (provided by applicant): Di-n-butyl phthalate (DBP) is a phthalic acid ester and a widespread environmental contaminant. DBP is a known reproductive toxicant in rats and mice, with adverse effects arising from the monoester metabolite - monobutyl phthalate (MBP). One principal uncertainty is the concentration of MBP required to impair human male reproductive development in utero. Mechanistic studies in rats have shown that in utero exposure to DBP decreases testosterone concentration in the fetal testes, possibly due to MBP-induced disruption in testosterone biosynthesis. The goal of this project is to develop a quantitative understanding of the relationship between DBP exposure and the concentration of MBP and testosterone in the fetal testes required to elicit an adverse response in rats. To accomplish this goal, a physiologically based pharmacokinetic (PBPK) model will be developed for rats to quantitatively understand the relationship between DBP exposure and the metabolism and distribution of its physiologically-active metabolite MBP. By understanding this dose-response relationship in rats, this model can be extrapolated to provide information on the real-world dangers of DBP to human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $0 )
2005	2005	CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY	POST OFFICE BOX 12137	RESCH TRIANGLE PK	NC	27709		USA	Resource and Manpower Development in the Environmental Health Sciences	000	2	7/1/2005	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2004 ( Subtotal = $47,296 )
2004	2004	CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY	POST OFFICE BOX 12137	RESCH TRIANGLE PK	NC	27709		USA	Resource and Manpower Development in the Environmental Health Sciences	000	1	6/14/2004	NEW	$47,296
														Subtotal = $47,296

Grand Total All Awards = $47,296

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PHARMACOKINETICS OF DBP IN UTERO TO ASSESS HUMAN RISK

Award Number: F32ES013370

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2004

PERIOD OF PERFORMANCE END DATE: 06/30/2006

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