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PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONS

Award Number: F32ES011061
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/15/2002
PERIOD OF PERFORMANCE END DATE: 02/06/2003

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PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONS - DESCRIPTION (Applicant's Abstract): is an environmental contaminant that has been shown to have antiandrogenic properties in vivo. Interestingly, DBP does not bind the androgen receptor in vitro so its mechanism of action, which is currently unknown, is likely mediated via a pathway different from that of other classic antiandrogens such as flutamide. The developing male fetus is very sensitive to alterations in androgen levels and even a slight perturbation by an antiandrogen may have profound long-lasting effects. When exposed to DBP during a late gestational window, the period of male reproductive tract development, males exhibit an altered reproductive tract phenotype when examined at postnatal day 100. These malformations include partially to completely absent epididymides, absent vasa deferentia and hypospadias. In addition, males exposed on GD 12 - 21 have decreased anogenital distances and increased incidence of thoracic nipple retention. To better understand the time course of development of DBP-induced lesions and the molecular alterations that precede these change, studies will be undertaken in the rat using an in utero exposure model. The proposed studies will test the hypothesis that there is altered gene expression of the fetal testicular steroidogenic enzymes and that it is alterations in these enzymes that lead to altered hormone levels and subsequent development of male reproductive tract lesions. A time course study will also be undertaken to better understand lesion development in DBP-exposed males. It is hoped that the data gained through these studies will help broaden our understanding of phthalate-induced reproductive lesions in the male rat and help determine the risk to humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2002	CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY	POST OFFICE BOX 12137	RESCH TRIANGLE PK	NC	27709		USA	Resource and Manpower Development in the Environmental Health Sciences	000	2	2/2/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2002 ( Subtotal = $55,015 )
2002	2002	CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY	POST OFFICE BOX 12137	RESCH TRIANGLE PK	NC	27709		USA	Resource and Manpower Development in the Environmental Health Sciences	000	2	4/12/2002	NON-COMPETING CONTINUATION	$55,015
														Subtotal = $55,015

Issue Date FY: 2001 ( Subtotal = $48,491 )
2001	2001	CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY	POST OFFICE BOX 12137	RESCH TRIANGLE PK	NC	27709		USA	Resource and Manpower Development in the Environmental Health Sciences	000	1	4/15/2001	NEW	$48,491
														Subtotal = $48,491

Grand Total All Awards = $103,506

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PATHOGENESIS OF PHTHALATE-INDUCED REPRODUCTIVE LESIONS

Award Number: F32ES011061

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/15/2002

PERIOD OF PERFORMANCE END DATE: 02/06/2003

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