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Characterizing a Circuit Linking Auditory Cortical Systems and the Social Behavior Network

Award Number: F32DC018508
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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PROJECT SUMMARY/ABSTRACT To engage in productive social interactions, the brain must coordinate processing of complex social sensory cues with production of appropriate social responses. Deficits in appropriate responses to social sensory cues are a feature of several prevalent neurological disorders, including frontotemporal dementia and autism spectrum disorders. While complex social signals (i.e., visual, auditory) are processed in cortex, nuclei controlling social behaviors (conserved across vertebrates), called the social behavior network (SBN), lie mainly in the diencephalon. Tremendous progress has been made in studying cortical sensory circuits and the SBN separately but apart from mammalian olfactory systems we are lacking basic knowledge of how information is coordinated between sensory cortex and SBN circuits. These connections are very likely to be critical for productive social interactions. The long-term goal of this training proposal is to characterize components of a circuit connecting auditory cortical regions with SBN nuclei. This research will be carried out in songbirds (specifically, Zebra finches; Taeniopygia guttata), which are ideal for realizing the proposal's long- term goal. Zebra finches learn and employ complex vocalizations in a rich variety of social contexts. In songbirds, complex social vocalizations induce immediate early gene labeling in both secondary auditory cortical regions and SBN nuclei. Lesions of secondary auditory cortex impair vocal recognition and mate preference, suggesting that cortical inputs to social nuclei play key roles in social decision-making. I have gathered preliminary data showing that secondary auditory cortical regions send projections to a region of the avian cortex, the medial arcopallium, and previous data demonstrate the medial arcopallium sends projections to several SBN nuclei. Based on these findings, this proposal hypothesizes that cortical auditory regions provide SBN nuclei with social-auditory input in part through this arcopallial region of the songbird cortex to influence behavioral decisions. The specific aims of my proposal will characterize this circuit through 1) testing how inactivation of auditory cortical regions during playback of social vocalizations alters immediate early gene measurements across SBN nuclei, 2) optogenetically identifying and stimulating synaptic connections between auditory cortex and the medial arcopallium, and 3) testing selectivity of medial arcopallial neurons for auditory- social stimuli in freely moving animals. This proposal will be the first to characterize an auditory cortical -> SBN circuit in vertebrates by bridging progress made in auditory systems neuroscience and research in the neural basis of social behavior. Deficits in social sensory cue processing and the ability to engage in social behavior are features of several neurological disorders. The findings generated by this proposal will open up new avenues for research on this vital function by expanding basic knowledge of coordination between cortical sensory circuits and social behavior nuclei.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$27,017 )
2023	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	001	3	5/15/2023	NON-COMPETING CONTINUATION	-$12,554
2023	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	10/17/2022	NON-COMPETING CONTINUATION	-$14,463
														Subtotal = -$27,017

Issue Date FY: 2022 ( Subtotal = $69,802 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	002	3	5/19/2022	NON-COMPETING CONTINUATION	$6
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	001	3	4/25/2022	NON-COMPETING CONTINUATION	$1,234
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	10/25/2021	NON-COMPETING CONTINUATION	$68,562
														Subtotal = $69,802

Issue Date FY: 2021 ( Subtotal = $66,410 )
2021	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	2	10/30/2020	NON-COMPETING CONTINUATION	$65,310
2021	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	001	2	2/2/2021	NON-COMPETING CONTINUATION	$1,100
														Subtotal = $66,410

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	001	1	11/20/2019	NEW	$0
2020	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	1	11/18/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $61,226 )
2019	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	1	8/22/2019	NEW	$61,226
														Subtotal = $61,226

Grand Total All Awards = $170,421

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Characterizing a Circuit Linking Auditory Cortical Systems and the Social Behavior Network

Award Number: F32DC018508

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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