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INHIBITION OF GENTAMICIN-INDUCED COCHLEAR HAIR CELL DEATH

Award Number: F32DC008235
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2006
PERIOD OF PERFORMANCE END DATE: 03/31/2008

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INHIBITION OF GENTAMICIN-INDUCED COCHLEAR HAIR CELL DEATH - DESCRIPTION (provided by applicant): Hearing loss is a significant problem with millions of Americans afflicted with some sort of hearing deficit. The primary targets of most agents that cause hearing loss are the cochlear hair cells. The loss of these specialized sensory receptors in mammals is permanent, however, chickens and other avian species are able to replace lost cochlear hair cells. This proposal has been designed to address prevention of cochlear hair cell death caused by gentamicin ototoxicity. The first set of experiments is designed to characterize what effect blocking different stages of the apoptotic cascade has on hair cell viability, and to determine if cochlear hair cell loss can be prevented in vitro. Once it is determined if gentamicin-induced cochlear hair cell death can be prevented in vitro, the second set of experiments investigates two in vivo methods of apoptosis inhibitor delivery to determine which one provides the best protection for cochlear hair cells. The data obtained here will provide important information regarding the prevention of cochlear hair cell death after gentamicin ototoxicity and the development of therapeutic tools that may help prevent hearing loss.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $96,472 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	5/23/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$49,646
2008	2008	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	3/21/2008	NON-COMPETING CONTINUATION	$46,826
														Subtotal = $96,472

Issue Date FY: 2006 ( Subtotal = $43,996 )
2006	2006	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	3/30/2006	NEW	$43,996
														Subtotal = $43,996

Grand Total All Awards = $140,468

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INHIBITION OF GENTAMICIN-INDUCED COCHLEAR HAIR CELL DEATH

Award Number: F32DC008235

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2006

PERIOD OF PERFORMANCE END DATE: 03/31/2008

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